2 EXERCISE EFFECTS ON 24H FAT OXID&FAT BAL IN LEAN,OBESE&WGT-REDUCED OBESE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 肥胖是一个严重的和日益严重的公共卫生问题，拟议的研究预计将提供重要的洞察力，生物学倾向于个人体重增加和恢复。 主要目的是a）确定肥胖症中脂肪代谢（脂解和/或氧化）是否受损，和B）这是否可以通过体重减轻逆转。 运动被提倡用于肥胖治疗，可能是通过其增加脂肪氧化的潜力，但似乎效果有限。 有证据表明，在运动过程中，肥胖和体重减轻的肥胖受试者的脂肪氧化减弱。 因此，次要目的是确定肥胖和减肥肥胖人群在运动期间的脂肪代谢是否受到运动强度的影响。 了解运动如何调节肥胖和减肥肥胖个体的脂肪代谢，对于了解体重调节的生理学至关重要。 这些研究的结果可能会导致更多的研究，以进一步解释为什么运动在预防和治疗肥胖中可能很重要。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity is a serious and increasing public health problem, and the proposed studies are expected to give important insight into the biology that predisposes individuals to weight gain and regain. The primary aims are a) to determine whether fat metabolism (lipolysis and/or oxidation) is impaired in obesity, and b) whether this can be reversed with weight loss. Exercise is advocated for obesity treatment, presumably through its potential to increase fat oxidation, but appears to have limited effectiveness. Evidence suggests that fat oxidation is blunted in obese and weight-reduced obese subjects during exercise. Thus, secondary aims are to determine in obese and weight-reduced obese humans whether fat metabolism during exercise is influenced by exercise intensity. Understanding how exercise regulates fat metabolism in obese and weight-reduced obese individuals is crucial in understanding the physiology of body weight regulation. Results from these studies could lead to additional studies to further explain why exercise may be important in the prevention and treatment of obesity.