CLINICAL TRIAL: FAT REDISTRIBUTION AND METABOLIC CHANGE IN HIV INFECTION: PROTOC

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 主要目标的分析将需要多变量方法来同时根据多个预测因子对内膜中层厚度（IMT）进行建模。 主要目标： 在4-5年的再分布和代谢范围（弗拉姆）研究中测量颈动脉IMT，并比较来自CARDIA和梅萨队列的HIV+受试者与对照受试者的结果，并调整HIV非依赖性风险因素，如年龄、性别、种族和吸烟。 确定IMT与传统危险因素（血脂）的关系， 代谢，葡萄糖耐量，脂肪分布，吸烟，身体 活动和血压）和促动脉粥样硬化炎性 标志物[C-反应蛋白（CRP）、派-1、纤维蛋白原、IL-6和 干扰素α]在肥胖弗拉姆参与者中测量， 1-2年初始弗拉姆研究访视和4-5年随访访视。 为了确定在动脉粥样硬化中观察到的增加的动脉粥样硬化的分数， HIV可归因于传统危险因素、新型心血管疾病（CVD）危险因素和HIV感染，以此作为确定目标的手段，供今后进一步调查干预。 为了确定IMT与单独使用抗逆转录病毒（ARV）药物（即，具体药物、药物类别）和组合。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Analyses of the primary aims will require multivariate methods to model intima-media thickness (IMT) in terms of several predictors simultaneously. Primary aims: To measure carotid IMT in years 4-5 of redistribution and metabolic range (FRAM) study and compare results in HIV+ subjects to control subjects from the CARDIA and MESA cohorts with adjustment for HIV-independent risk factors, such as age, sex, race, and smoking. To determine the association of IMT with traditional risk factors (lipid metabolism, glucose tolerance, fat distribution, smoking, physical activity and blood pressure) and with pro-atherosclerotic inflammatory markers [C-reactive protein (CRP), PAI-1, fibrinogen, IL-6, and interferon alpha] measured in fat FRAM participants in samples from the Yr 1-2 initial FRAM Study visit and at the Yr 4-5 follow-up visit. To determine the fraction of the increased atherosclerosis observed in HIV that can be attributed to traditional risk factors, novel cardiovascular disease (CVD) risk factors and HIV infection as a means for identifying targets for future intervention of further investigation. To determine the association of IMT with usage of antiretroviral (ARV) agents alone (i.e., specific drugs, classes of drugs) and in combination.