GENETIC AND EXPERIENTIAL FACTORS INFLUENCING FUNCTIONAL ORGANIZATION OF MOTOR

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 运动障碍是中风后观察到的主要功能缺陷。超过80%的中风患者表现出某种形式的运动障碍，其中上肢损伤是最常见的。中风后的运动康复通常可以显著改善运动功能，这取决于损伤的严重程度和位置(Duncan等人，2000年)。尽管运动恢复的具体神经机制尚不清楚，但最近的神经成像和皮质刺激实验表明，残存神经组织内的功能代偿。康复导致的运动表现的改善可以改变与运动相关的皮质活动的模式(Cramer，2002)，以及刺激的轨迹在完整的皮质组织中引起的运动表征(Nudo等人，1996；Kleim等人，2003)。通过运动康复恢复运动可以通过在完整运动区内进行功能重组来支持。了解那些影响运动皮质重组能力的因素将有助于开发促进中风后运动恢复的假定治疗干预措施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Motor impairments represent the primary functional deficit observed following stroke. Over 80% of all stroke victims exhibit some form of movement disability with upper extremity impairments being the most common. Post stroke motor rehabilitation can often significantly improve motor function depending on the severity and location of the damage (Duncan et al., 2000). Although the specific neural mechanisms underlying motor recovery are unknown, recent neural imaging and cortical stimulation experiments have implicated functional compensation within residual neural tissue. Rehabilitation induced improvements in motor performance can alter both the pattern of cortical activity associated with movement (Cramer, 2002) and the locus of stimulation evoked movement representations within intact cortical tissue (Nudo et al., 1996; Kleim et al., 2003). Restoration of movement through motor rehabilitation may be supported by functional reorganization within intact motor areas. Understanding those factors contributing to the capacity for motor cortex reorganization will contribute to the development of putative therapeutic interventions for enhancing motor recovery after stroke.