TAP03071 - SUB-STUDY OF ENROLLMENT OF NORMAL CONTROL SUBJECTS FOR CURRENT AND F

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 正常对照的使用是广泛的生物医学研究的关键要求。组织捐献计划(TDP)已经建立了一项协议(TAP0307)，以登记愿意参与研究的正常受试者队列。TAP0307包括收集关于这些受试者的有限数量的人口统计和临床数据，以及收集和存储从唾液/漱口水样本中提取的DNA。我们现在正在提出一项具有以下目标的子议定书。 这项子研究(TAP0307.1)的具体目标是根据三个特定基因中的一个存在正常遗传变异来识别和招募对照受试者。我们将确定已经在TAP0307注册的受试者，这些受试者携带三个相关基因的共同变异：MIF、MMP-1和PTPN22。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The use of normal controls is a critical requirement for a wide variety of biomedical research. The Tissue Donation Program (TDP) has already established a protocol (TAP0307) in order to register a cohort of normal subjects who are willing to participate in research studies. TAP0307 includes the collection of a limited amount of demographic and clinical data on these subjects, as well as the collection and storage of DNA derived from saliva/mouthwash samples. We are now proposing a sub-protocol with the following aim. The specific aim of this sub-study (TAP0307.1) is to identify and recruit control subjects based on the presence of normal genetic variation in one of three specific genes. We will identify subjects already registered in TAP0307 who carry common variants in three genes of interest: MIF, MMP-1 and PTPN22.