REASONING AND DECISION-MAKING STUDIES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这个项目的主要目标是研究ADHD儿童推理和决策的神经病理生理学，兴奋剂药物对其的调节，以及它是否因多巴胺基因而异。纹状体多巴胺能系统与ADHD有关，我们想要进一步研究这一点。在对ADHD和对照受试者(7-25岁)进行的一系列研究中，我们将使用功能磁共振成像(FMRI)检查大脑功能，并使用实验室实验任务检查推理和决策过程中的行为功能。进一步，我们将检查大脑和行为的个体差异是否与包括DAT1、DRD4和COMT在内的多巴胺能基因的多态性有关。此外，在ADHD受试者中，我们还将检查推理和决策过程中的大脑和行为测量是否对刺激性药物敏感。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major goal of this project is to examine the neuropathophysiology of reasoning and decision-making in ADHD children, its modulation by stimulant medication, and whether it varies by dopamine genes. The striatal dopaminergic system has been implicated in ADHD and we would like to investigate this further. In a series of studies with ADHD and control subjects (Ages 7-25), we will examine brain function using functional magnetic resonance imaging (fMRI) and behavioral function using laboratory experimental tasks during reasoning an decision-making. Further, we will examine whether individual differences in brain and behavior relate to polymorphism of dopaminergic genes including DAT1, DRD4, and COMT. Further, in subjects with ADHD, we will also examine whether brain and behavioral measures during reasoning and decision-making are sensitive to stimulant medication.