GENOME SCREEN FOR ASTHMA SEVERITY MODIFER POLYMORPHISMS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项拟议研究的目的是了解导致哮喘患者慢性哮喘严重程度差异的基因变异。在这项建议中，我们将生成一份由文献搜索确定的哮喘相关基因的20个自然发生的多态变异的列表。同时，我们将对1500名具有不同种族背景的哮喘儿童进行队列研究，男女人数相等。这些患者将接受基因分型和访谈，以评估慢性哮喘的严重程度，以及药物、药物干预和环境暴露史。然后，这些“临床”数据将与多态数据相关联，以识别那些自然发生的变异，这些变异在控制药物、医疗干预和环境暴露史的同时，显示出与慢性哮喘严重程度的统计上的显著关联。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of the proposed study is to understand the genetic variation leading to differences in chronic asthma severity between asthmatic individuals. In this proposal we will generate a list of 20 naturally occurring polymorphic variants in asthma-associated genes determined by a literature search. In parallel, we will conduct a cohort study of 1,500 asthmatic children representative of multiple ethnic backgrounds, with equal numbers of males and females. These patients will be genotyped and interviewed to assess chronic asthma severity, as well as medication, medication intervention, and environmental exposure history. This "clinical" data will then be correlated with the polymorphism data to identify those naturally occurring variants, which show a statistically significant association with chronic asthma severity while controlling for medication, medical intervention, and environmental exposure history.