TREATMENT WITH MINOCYCLINE GEL 2% IN ADULTS WITH PERIODONTAL DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究是为了确定Periocline凝胶与机械治疗牙周病的联合使用的有效性。牙周病的机械治疗包括深度清洁(去垢和根面平整)。派丽奥平凝胶具有抗生素(米诺环利)的活性成分。米诺环素是四环素类抗生素中的一员，已被证明对微生物安全有效。 40名患有牙周病的成年人，身体健康，对米诺环素不过敏，将参加这项研究。将有3个小组进行研究。 第1组：该组将接受深度清洁和假治疗。假治疗包括注射，其中不会使用任何试剂。 第2组：深度清洁和活性药物(米诺环素)。 第3组：这组人将接受深度清洁和安慰剂，一种看起来像活性药物但不含活性成分的药剂。 将向所有受试者提供基线上的平整和根面平整。所有受试者都将在基线、2周和4周、3个月和6个月接受假治疗、安慰剂或周期疗法。研究将在9个月完成。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is being done to determine effectiveness of Periocline Gel when used in combination with mechanical treatment of gum disease. Mechanical treatment of gum disease includes deep cleaning (scaling and root planing). Periocline Gel has the active ingredient of an antibiotic (Minocyclie). Minocycline is a member of the tetracycline class of antibiotics, and has been proven to be safe and effective against microbes. 40 adults with gum disease, of general good health and no allergy to Minocycline, will be enrolled to participate in this study. There will be 3 groups studied. Group 1: This group will receive deep cleaning and sham treatment. Sham treatment consists of an injection where no agent will be used. Group 2: This group will receive deep cleaning and active drug (Minocycline). Group 3: This group will receive deep cleaning and placebo, an agent that looks like the active drug but contains no active ingredients. All subjects will be provided the scaling and root planing at baseline. All subjects will receive sham, placebo, or periocline treatment at baseline, weeks 2 and 4, and months 3 and 6. Study completion will be at 9 months.'