Training in Translational Science and Cardiovascular Medicine

描述（由申请人提供）：本修订提案旨在为应用于心血管疾病的转化研究的新培训计划提供资金。该计划将通过俄勒冈州健康与科学大学心血管医学部和心脏研究中心招募博士和医学博士学员。六名博士后研究员将获得两年研究培训的资助。该计划将提供令人兴奋的机会，在五个已建立的小组之一，专门从事1）成人疾病的早期起源，2）肥胖/糖尿病，3）细胞信号传导，4）生理系统和5）人类研究。34名教师是高度认可和资助的科学家，他们在培养博士后研究员方面有着良好的记录。专业培训将包括分子成像，小鼠遗传模型，肥胖和心血管疾病的灵长类动物模型，临床MRI研究，机械力-基因表达联系，心血管失调的数学模型。实验室研究将通过课程工作，研讨会，期刊俱乐部和特定科学小组内的会议进行补充。该计划在OHSU是独一无二的，因为指导将以团队的方式进行。每位学员的指导委员会将由一名基础科学家和一名临床科学家以及一名额外的科学家组成。培训成果将是具有广阔前景的科学家，并专注于使科学造福于患者。该申请包括针对服务不足的少数族裔学员的强大招聘计划和评估流程。一个强大的计划咨询委员会将监测每个学员的进展，因为他们满足特定的里程碑，为研究生涯做准备。这些从该计划毕业的科学家将准备调查主要的公共卫生问题，包括中风，糖尿病，冠心病，心力衰竭和肥胖症日益增加的全球负担。

DESCRIPTION (provided by applicant): This revised proposal seeks funds for a new training program in translational research applied to cardiovascular disease. The program will recruit PhD and MD trainees through the Division of Cardiovascular Medicine at the Oregon Health & Science University and the Heart Research Center. Six post-doctoral fellows will be offered funding for two years of research training. The program will offer exciting opportunities for bench to bedside training in one of five established groups that specialize in 1) the early origins of adult disease, 2) obesity/diabetes, 3) cell signaling, 4) physiological systems, and 5) human research. The 34 faculty are highly recognized and funded scientists who have a track record of training postdoctoral fellows. Specialty training will include molecular imaging, mouse genetic models, primate models of obesity and cardiovascular disease, clinical MRI research, mechanical forces-gene expression links, mathematical models of cardiovascular dysregulation. Laboratory research will be supplemented by course work, seminars, journal club, and meetings within a specific science group. This program is unique at OHSU in that mentoring will be carried out in a team approach. A basic scientist and a clinical scientist plus one additional scientist will serve on each trainee's mentoring committee. The training outcome will be scientists with a broad outlook and a focus on bringing science to the benefit of patients. The application includes a strong recruitment program for underserved minority trainees and an evaluation process. A strong Program Advisory Committee will monitor the progress of every trainee as they meet specific mileposts in preparation for a research career. These scientists that graduate from this program will be prepared to investigate major public health issues including the increasing global burden of stroke, diabetes, coronary heart disease, heart failure and obesity.