Core 4: Genetics Core

遗传学核心的目的是对研究项目收集的基因组DNA样本进行遗传分析。人类和灵长类动物样本的集中式基因分型将通过利用一致的方法执行和解释基因分型数据，从而最大限度地提高我们的效率。这个核心将 有四个主要目标，即a)从单个项目的外周血液或唾液中提取基因组DNA；b)在人类和灵长类样本中对5-HTTLRR 5-HTTLRR进行基因分型；c)在人类样本中对单核苷酸多态(SNPs)和5个5-羟色胺相关基因的重复多态进行分型；以及在人类样本的复制样本中对显示遗传关联的DNA变体进行DJ分型。该核心将与这些项目以及生物统计和成像核心密切合作，以便能够有效地分享和分析基因数据。

The purpose of the GENETICS CORE is to provide for genetic analysis of genomic DNA samples collected by the Research PROJECTS. Centralized genotyping of human and primate samples will maximize our efficiency by utilizing consistent methods for carrying out and interpreting genotyping data. This CORE will have four primary goals, which are to a) extract genomic DNA from peripheral blood or saliva from individual PROJECTS; b) to genotype the serotonin transporter promoter repeat polymorphism 5-HTTLRR in human and primate samples; c) to genotype single nucleotide polymorphisrns (SNPs) and a repeat polymorphism from five serotonin-related genes in human samples; and dj to genotype DNA variants showing genetic association in a replication sample of human samples. The CORE will work closely with the PROJECTS and with the biostatistics and imaging COREs to allow efficient sharing and analysis of genotypic data.