Genomics Shared Resources

西蒙斯癌症中心(SCC)基因组学共享资源(GSR)的使命是提供建议、培训和 使成员能够使用高通量基因组和蛋白质组进行癌症相关研究 表情分析。GSR通过以下方式促进方案内和方案间的癌症特异性研究 提供关于最佳使用最先进的遗传和蛋白质组平台的培训和建议 大学核心。GSR的典型用户在癌症的各种计划内和之间进行交互 中心。GSR的使用者包括德克萨斯州肺癌西南孢子的成员(分子 治疗学、癌细胞网络、化学和癌症)，德克萨斯大学西南NSCOR计划 (分子治疗)，癌症和化学(化学和癌症)计划项目赠款，以及 乳腺癌和前列腺癌的各种疾病导向团队(分子治疗、开发 和癌症)。研究人员在CRNA中进行实验，并使用CRNA共享研究数据库 (微阵列)、siRNA寡聚体和/或shRNA慢病毒介导的筛选、aCGH分析、SNP分析、 和GSR提供的蛋白质表达微阵列分析。癌症中心的研究人员和他们的 相关工作人员直接与GSR主任和技术顾问互动，如下所示：Michael Story博士 (基因组学：基因和miRNA表达、aCGH、甲基化和SNP分析) 或Woody Wright博士(基因敲除：siRNA和shRNA 击倒分析)，在试验之前，通过咨询以确保资源的有效利用， 包括大学核心资源。GSR的未来发展依赖于癌症的投入 癌症中心的中心成员、项目和高级领导，我们的内部顾问委员会成员， 以及(通过内部或外部来源)招聘可用的技术顾问。GSR在以下方面保持灵活性 它的当前和未来发展，最近注意到最近列入了QDot反相 蛋白质组微阵列(QdoRPPM)、shRNA慢病毒文库筛选和深度测序能力。

The mission of the Simmons Cancer Center (SCC) Genomics Shared Resource (GSR) is to advise, train and enable members to perform cancer-related research using high throughput genomic and proteomic expression analyses. The GSR facilitates both intra- and inter-programmatic cancer-specific research by offering training and advice on the best use of state-of-the-art genetic and proteomic platforms provided by the University Core. Typical users of the GSR interact within and between various Programs of the Cancer Center. Users of the GSR include members of the UT Southwestern SPORE in lung cancer (Molecular Therapeutics, Cancer Cell Networks, Chemistry and Cancer), The UT Southwestern NSCOR Program (Molecular Therapeutics), the Program Project Grant in Cancer and Chemistry (Chemistry and Cancer), and the various disease-oriented teams in breast and prostate cancers (Molecular Therapeutics, Development and Cancer). Researchers perform experiments in, and share research databases using, cRNA (microarray), siRNA oligomer and/or shRNA lenfiviral-mediated screening, aCGH analyses, SNP analyses, and protein expression microarray analyses provided by the GSR. Cancer Center investigators and their related staff interact direcfiy with the GSR director and technology advisors, as follows: Drs. Michael Story (Genomics: gene and miRNA expression, aCGH, methylation and SNP analyses), Chin-Rang Yang (Proteomics: Qdot RPPM expression analyses), or Dr. Woody Wright (Gene Knockdown: sIRNA and shRNA knockdown analyses), prior to experimentation, through consults to ensure efficient use of resources, including University Core Resources. Future development of the GSR is dependent on input from Cancer Center members, Program and Senior Leaders of the Cancer Center, our internal advisory board members, and recruitment (by internal or external sources) of available technical advisors. The GSR remains flexible in its current and future development, most recently noted by the recent inclusion of Qdot reverse-phase proteomic microarray (Qdot RPPM), shRNA lentiviral library screening, and deep sequencing capability.