Fox Chase Cancer Center Breast Cancer Tissue Resources

PROV！_ n_n， 由于缺乏足够数量的患者标本， ：缺乏足够的随访或患者信息，治疗方式的可变性， 计算机化系统来检索用于执行这些研究的所需病例。因此，需要的是一个 乳腺癌组织资源，能够提供足够数量的存档乳腺组织， 研究人员根据疾病的阶段、治疗方式、随访， 充分的组织学诊断、淋巴结状态、肿瘤分级和其他人口统计学数据，如年龄、绝经 地位和种族等等。为了满足这些需求，我们组织了Fox Chase癌症组织资源 （FCCC-BCTR）。FCCC-CBCTR是创建国家癌症研究所的四大支柱之一 乳腺组织资源合作组织（NCI-CBCTR）。在过去八年中， NCI-CBCTR数据库中共有9，000例病例，其中超过2，859例病例。收集的案例 包含存档的石蜡组织，人口统计学数据，病理学，临床，治疗及其各自的临床 随访最近，我们一直在开发组织芯片，作为一种更有效的方式来提供大量的 用最少的资源给研究人员。基于这一贡献，我们提出以下建议 作为NCI-CBCTR的一部分，维护FCCC乳腺组织资源的具体目标：1：提供 组织切片和相关的临床数据提供给研究者，其申请已被推荐用于 由REP根据优点和内容批准，并由NCI-CBCTR批准。这项工作将在合作中完成 NCI-CBCTR的其他资源。2：积极参与组织芯片的建设 并进一步分发给研究者，其申请已被REP和 NCI-CBCTR。这项工作将与NCI-CBCTR的其他资源合作进行。3：向 保持新病例的充分积累，以便补充使用过的存档组织。4：向 构建正常乳腺组织的组织微阵列，并进一步分发给研究者， 已由REP和NCI. CBCTR推荐批准。5、保持足够的质量 FCCC-CBCTR中的控制。6：充分参与国家癌症研究所协调委员会的运作 合作乳腺癌组织资源，并与研究评价小组7合作： 通过适当的营销活动鼓励使用NCI-CBCTR。

PROV!_n_n, A definitive evaluation of tumor markers has been hindered by a lack of adequate number of patient's specimens and :the lack of adequate follow-up or patient information, the variability in therapeutic modalities, and poor computerization systems to retrieve the desired cases for performing these studies. Therefore, what is needed is a breast cancer tissue resource that would be able to provide archival breast tissue in sufficient amount to allow researchers to draw valid statistical conclusions, based on the stage of the disease, treatment modality, follow-up, adequate histological diagnosis, lymph node status, tumor grading and other demographic data such age, menopausal status and race among others. For answering these needs we have organized the Fox Chase Cancer Tissue Resources (FCCC-BCTR). The FCCC-CBCTR has been one of the four pillars for the creation of the National Cancer Institute Cooperative Breast Tissue Resources (NCI-CBCTR). The FCCC-BCTR has contributed during the last eight years with more than 2,859 cases to the total of 9,000 cases available in the NCI-CBCTR database. The collected cases contain the archival paraffin tissue, data on demography, pathology, clinic, treatment, and their respective clinical follow-up. Recently we have been developing the tissue microarray as a more efficient way to provide large amount of cases with minimal amount of resources to the researchers. Based on this contribution we propose the following specific aims for the maintenance of the FCCC Breast Tissue Resources as part of the NCI-CBCTR: 1: To provide tissue sections and pertinent clinical data to investigators whose applications have been recommended for approval by merit and content by REP and approved by the NCI-CBCTR. This work will be done in cooperation with the other resources of the NCI-CBCTR. 2: To actively participate in the construction of tissue microarray and further distribution to investigators whose applications have been recommended for approval by REP and by the NCI-CBCTR. This work will be done in cooperation with the other resources of the NCI-CBCTR. 3: To imaintain an adequate accrual of new cases that allows a replenishment of the used archival tissue. 4: To construct tissue microarray of normal breast tissue and further distribution to investigators whose applications have been recommended for approval by REP and by the NCI.CBCTR. 5: To maintain an adequate quality control in the FCCC-CBCTR. 6: To fully participate in the functioning of the coordinating Committee of the NCI Cooperative Breast Cancer Tissue Resource and to collaborate with the Research Evaluation Panel 7: To encourage the utilization of the NCI-CBCTR through an adequate marketing initiative.