Integrative Biostatistics and Informatics Core

综合生物统计学与信息学核心 综合生物统计和信息学核心(IBIC)将为MNORC研究基地调查人员进行的临床前、临床和转化性研究提供实验设计、数据管理和分析方面的专业知识。该中心将继续与计算医学和生物信息学中心(CCMB)、国家综合生物医学信息学中心(NCIBl)、密歇根临床和卫生研究所(MICHR)以及生物识别和结果研究核心(BORC)进行重要互动，以提供这些服务。该中心将支持临床前和临床研究的数据库设计。临床相关数据库将是符合《健康保险可携带性和责任法案》(THIPAAJ)的。 该核心还将为相关数据库的数据挖掘提供专门知识和工具，并在使用各种工具分析基因组、转录组、代谢组和蛋白质组数据方面提供援助和培训。可用的工具将允许在时间上或与作为临床研究一部分收集的表型参数相关的数据的整合和分析。 最后，IBIC人员将与以太核心和研究体重管理诊所合作，开发适当的数据格式和数据库结构，将临床、分子、神经行为和其他表型数据整合为便于生物统计和信息学方法分析的格式。

Integrative Biostatistics and Informatics Core The Integrative Biostatistics and Informatics Core (IBIC) will provide expertise in experimental design, data management and analysis for preclinical, clinical and translational research studies conducted by MNORC Research Base investigators. The Center will continue important interactions with the Center for Computational Medicine and Bioinformatics (CCMB), the National Center for Integrative Biomedical Informatics (NCIBl), the Michigan Institute for Clinical and Health Research (MICHR) and the Biometrics and Outcomes Research Core (BORC) to provide these services. The Core will support database design for both preclinical and clinical studies. Clinically relevant databases will be Health Insurance Portability and Accountability Act (THIPAAJ compliant. The Core will also provide expertise and tools for data mining of relevant databases as well as assistance and training in the use of various tools for analysis of genomic, transcriptomic, metabolomic and proteomic data. Available tools will allow the integration and analysis of data in temporally or in relationship to phenotypic parameters collected as part of clinical studies. Finally, IBIC personnel will collaborate with ether Cores and the Investigational Weight Management Clinic to develop appropriate data formats and database constructs to integrate clinical, molecular, neurobehavioral and other phenotypic data into formats that ease analysis by biostatistical and informatics methodologies.