Oligopyrrole-based Anion Binding Agents

该项目的长期目标是使用基于聚吡咯的阴离子受体 了解调控阴离子识别和运输过程的基本因素 在生物学方面，并开发对诊断和治疗癌症有用的合成系统 人类疾病。这个为期两年的项目具体涉及1)高 亲和受体将允许在水存在时识别阴离子，特别是 以氯化物和磷酸盐为目标，以及2)使用这些试剂来创建新的聚合物 具有阴离子特定识别特性的体系，并证明后者 聚合物可以用来隔离界面下的磷酸盐和其他阴离子 条件。重点将放在杯状吡咯和吡咯酰胺受体上，这些受体依赖于 施主集合，并利用新的阴离子识别基序(例如，CH-阴离子 氢键、局域电荷和离子配对相互作用)和受控几何 (例如，通过捆绑一个感受器表面来实现)以达到必要的高度 亲和力而不动。允许官能化和聚合。 预计到这个为期两年的项目完成时，一套新的 基于聚合物的萃取剂将在手中，然后可以进一步开发，最终 用于控制终末期肾脏疾病，其中清除磷酸阴离子代表一种 重要的未解决的问题。

The long-range goals of this project are to use polypyrrole-based anion receptors to understand the fundamental factors that regulate anion recognition and transport processes in biology and to develop synthetic systems that are useful in the diagnosis and treatment of human disease. This two-year project is concerned specifically with 1) the design of high- affinity receptors that will allow for anion recognition in the presence of water, especially those targeting chloride and phosphate, and 2) using these agents to create new polymeric systems with anion-specific recognition properties and demonstrating that these latter polymers may be used for the sequestration of phosphate and other anions under interfacial conditions. The focus will be on calixpyrrole and pyrrole-amide receptors that rely on multiple donor sets and which take advantage of new anion recognition motifs (e.g., CH-anion hydrogen bonds, localized charges,and ion-pairing interactions) and controlled geometries (achieved through strapping one receptor face, for instance) to achieve the requisite high affinity while still. Permitting functionalization and polymerization. The expectation is that by the time this two-year project is complete, a new set of polymerbased extractants will be in hand that could then be developed further for eventual use in the control of end-stage renal disease, where phosphate anion removal represents an important unsolved problem.