Pre-doctoral Training Program in Integrative Vascular Biology

描述(申请人提供)：心血管疾病的发病机制是复杂的。因此，我们建议通过在博士前培训期间开始的多学科合作，培养未来的血管生物学家，能够实施结合“细胞”、“整个动物”和“人类”系统的综合方法。跨学科的Pre 北卡罗来纳大学的综合血管生物学(IVB)博士培训项目成立于2002年，有效地团结了在血管生物学的广泛学科工作的研究生。IVB方案的成功清楚地体现在以下事实上：42名受训人员中有18人在接受培训期间获得了个人奖学金，27名过去完成博士学位的受训人员中有22人在学术环境中继续进行研究，或者是医学院的住院医生/学生。该计划的目的是(1)联系与血管生物学相关的广泛研究领域的研究生，并培养他们的沟通和合作能力；(2)通过合作促进合作 不同部门的导师，从而整合了与学员论文研究相关的广泛知识库和技能集。本次续签申请要求提供资金以继续我们的IVB计划，每年支持12名学员，每名学员最长可达三年。在这次更新中，一个新的方法是从代表不足的少数族裔背景中寻找优秀的学生，并在第一年引导他们对血管生物学的兴趣；其中一个受训职位将被专门分配来支持这位研究员。其他学员将从已经在北卡罗来纳大学的系研究生课程中挑选，并在第一年或第二年结束时选择了与血管生物学相关领域的论文项目/导师。为了鼓励多学科的方法，我们要求每个学员除了他们传统的主要导师外，还有一位协作导师(S)。IVB项目由全校分子生物学和生物技术项目管理。病理和实验室医学教授前田信洋博士是主任，凯瑟琳·卡隆博士是ASSOC。细胞和分子生理学教授和生物化学和生物物理学教授兼主席Leslie Parise是副主任。主要导师是北卡罗来纳大学的教职员工，他们来自四所学校和一所学院的13个系，所有这些系都坚定地致力于通过血管生物学相关研究进行博士前培训。为了组成一个互补的教员队伍，学员可以选择与之合作，北卡罗来纳大学的临床教员和研究人员加入了初级培训教员的行列，他们保持着活跃的实验室，主要工作人员是博士后研究员。对IVB社区的支持也通过McAlister心脏研究所提供，该研究所提供一系列研讨会和核心设施来研究血管生物学。北卡罗来纳大学的IVB项目凭借其在血管生物学研究方面的卓越历史和广度，其强大的研究团队和在动物模型研究方面的实力，为博士前学生的多学科培训提供了理想的环境。(摘要结束)

DESCRIPTION (provided by applicant): The pathogenesis of cardiovascular diseases is complex. Accordingly, we propose to train future vascular biologists capable of implementing integrated approaches combining "cellular", "whole animal" and "human" systems through multidisciplinary collaborations that begin during pre-doctoral training. The interdisciplinary pre doctoral training program in Integrative Vascular Biology (IVB) at the University of North Carolina was established in 2002 and has effectively united graduate students who are working in broad disciplines of vascular biology. The success of the IVB Program is clearly demonstrated by the fact that 18 of the 42 trainees received individual fellowships while they were/are in training, and that 22 of 27 past trainees who completed their PhDs are continuing research in academic settings or are residents/students at Medical Schools. The program aims (1) To connect graduate students in broad areas of research related to vascular biology and to cultivate their communication and collaboration skills; (2) To facilitate collaborations through co mentors in different Departments, and thereby integrate a broad knowledge base and skill set relevant to the trainee's thesis research. This renewal application requests funding to continue our IVB Program with support for 12 trainees per year, each up to three years. A new approach in this renewal is to identify outstanding students from under-represented minority backgrounds and guide their vascular biology interest during their first year; one of the trainee positions wil be specifically assigned to support this Fellow. Other trainees will be selected among those who are already in departmental graduate programs at UNC and have chosen thesis projects/mentors in areas related to vascular biology at the end of their first or second year. To encourage a multi-disciplinary approach, we require each trainee to have a collaborating advisor(s) in addition to their conventional primary mentor. The IVB Program is administered by the campus-wide Program for Molecular Biology and Biotechnology. Dr. Nobuyo Maeda, Prof. of Pathology and Laboratory Medicine, is the Director, and Drs. Kathleen Caron, Assoc. Prof. of Cell and Molecular Physiology, and Leslie Parise, Prof. and Chair of Biochemistry and Biophysics, are the Associate Directors. The primary mentors are faculty members at UNC from 13 Departments in four Schools and one College, all of which have a strong commitment to predoctoral training through vascular biology-related research. To form a body of complementing faculty with whom the trainees can choose to collaborate, the primary training faculty are joined by clinical faculty and investigators at UNC who maintain active laboratories staffed primarily with postdoctoral fellows. Support for the IVB community is also provided through the McAlister Heart Institute which offers a seminar series and Core facilities to study vascular biology. With its outstanding history and breadth in vascular biology research, its strong group of investigators, and its strength in animal model studies, the IVB Program at UNC offers an ideal environment for the multidisciplinary training of pre-doctoral students. (End of Abstract)