Preventing Drug Abuse among Hispanic Adolescents

描述（由申请人提供）：重新提交的申请解决了在初步审查中发现的弱点。为响应PAS-09-001，与临床和转化科学奖联盟（R 01）合作进行的药物滥用流行病学和服务研究，该应用程序计划开发，测试和传播一个互动程序，以延迟药物使用的开始，并防止西班牙裔青年的有害使用和滥用。研究参与者将来自北方曼哈顿，那里居住着大量来自多米尼加、波多黎各和其他背景的西班牙裔家庭。基于双文化能力和社会学习理论，预防计划将使青少年具备认知和行为技能，以解决与西班牙裔青少年吸毒相关的种族特异性和泛种族风险和保护因素。青少年将通过个人电脑访问该计划的10个初始会议和年度助推器会议。通过一个人类模拟互动平台，该计划将采用人工智能，情感状态的图形描绘，以及一个分支学习环境，青少年可以在其中获得，尝试，接收反馈并掌握新的人际交往技能。文化内容编织到每一个节目会议，连同会议明确致力于文化适应问题，西班牙裔传统，和双文化压力将使节目主题的连贯性，并提高其吸引力和价值。研究设计为随机临床试验。参加的11岁、12岁和13岁的青少年将完成基线测量，干预组青少年将接受初步预防方案，所有青少年将完成干预后和12个月、24个月和36个月的随访测量。干预组的年轻人在完成12个月和24个月的随访测量后，还将接受成对的助推器治疗。假设检验分析将检查组间和随访测量时间的30天药物使用率。此外，我们还将分析与药物使用风险和保护因素相关的中介变量的干预效果。我们还将评估中介变量的变化在多大程度上解释了药物使用的差异。而且，我们将研究性别差异，并在可能的范围内，研究结果中的移民身份和种族背景差异。在试验结束时，假设纵向研究结果支持测试的预防方法，我们将修改该计划，以增加其对美国西班牙裔青年的吸引力，我们将通过各种在线资源传播修订后的计划。在整个过程中，我们将监控计划的传播。 公共卫生相关性：这项研究将纵向测试西班牙裔青少年的计算机化药物滥用预防计划。针对文化的预防方案旨在加强和维持保护因素，同时为青年人提供必要的信息和技能，以减少与吸烟、酗酒、大麻和其他有害药物使用有关的风险因素。

DESCRIPTION (provided by applicant): This resubmitted application addresses the weaknesses identified in its initial review. Prepared in response to PAS-09-001, Drug Abuse Epidemiology and Services Research in Cooperation with the Clinical and Translational Science Awards Consortium (R01), the application lays plans to develop, test, and disseminate an interactive program to delay the onset of drug use and to prevent harmful use and abuse among Hispanic youths. Study participants will come from Northern Manhattan, home to a large population of Hispanic families from Dominican, Puerto Rican, and other backgrounds. Grounded in bicultural competence and social learning theories, the prevention program will equip youths with cognitive and behavioral skills to address ethnic-specific and pan-ethnic risk and protective factors associated with drug use among Hispanic adolescents. Youths will access the program's 10 initial sessions and annual booster sessions via personal computer. Through a human simulation interaction platform, the program will employ artificial intelligence, graphic portrayals of emotional states, and a branched learning environment in which youths can acquire, try out, receive feedback on, and master new interpersonal skills. Cultural content woven into every programmatic session, together with sessions expressly dedicated to issues of acculturation, Hispanic traditions, and bicultural stress will give the program thematic coherence and enhance its attraction and value. The study design is a randomized clinical trial. Enrolled 11-, 12-, and 13-year-old youths will complete baseline measures, intervention-arm youths will receive the initial prevention program, and all youths will complete post-intervention and 12-, 24-, and 36-month follow-up measures. Intervention-arm youths will additionally receive pairs of booster sessions after they complete 12- and 24-month follow-up measurements. Hypothesis testing analyses will examine 30-day drug use rates between arms and across follow-up measurement occasions. In addition, we will analyze intervention effects on mediator variables associated with drug use risk and protective factors. We also will assess the extent to which changes on mediator variables explain drug use differences. And, we will examine gender differences, and, to the extent possible, immigration status and ethnic background differences in study outcomes. At the conclusion of the trial, and assuming that longitudinal findings support the tested prevention approach, we will revise the program to increase its appeal for Hispanic youth across America, and we will disseminate the revised program through a variety of online resources. Throughout, we will monitor program dissemination. PUBLIC HEALTH RELEVANCE: This study will longitudinally test a computerized drug abuse prevention program for Hispanic adolescents. The culturally-tailored prevention program aims to strengthen and sustain protective factors while equipping youths with the necessary information and skills to reduce risk factors associated with cigarettes, alcohol, marijuana, and other harmful drug use.