Women's Health and the Environment over the Entire Lifespan (WHEEL)

描述（由申请人提供）：在过去10年中，人们对环境化学品对人类和环境健康的潜在影响的担忧大大增加。通过对荷尔蒙途径的影响，环境化学品可以对女性产生不同的影响，特别是在整个生命周期的关键和敏感时期。这些关键时期包括特别脆弱的阶段（如胎儿发育和老年人），主要的生命过渡阶段（如中年和晚年），以及快速细胞增殖和生长阶段（如胎儿发育，青春期和哺乳期）。罗切斯特大学医学中心（URMC）的妇女健康与环境终生计划（WHEEL）重点关注跨学科研究，具体涉及以下交叉点：妇女健康、环境和生命阶段特有的健康问题。它将建立在研究生培训计划已经在URMC到位，并补充这些教育培训和研究经验，旨在满足计划内的学者的需求。该方案将培训来自一系列学科的跨学科妇女健康研究学者，并最终促进研究和成果的翻译，这将有利于妇女的健康，特别是在妇女整个生命周期的环境健康领域。我们的长期目标是：1）“毕业”学者谁去成功的职业生涯在跨学科研究在妇女的环境健康; 2）建立一个成功的和可持续的培训计划，在妇女的健康研究; 3）在URMC创造有利于妇女健康跨学科研究的环境，4）培养对研究环境和妇女健康研究领域提供积极反馈的研究人员，5）建立持续机制，有效地将妇女健康研究成果转化给卫生专业人员和更广泛的社区。 公共卫生相关性：在过去十年中，公众和科学界对环境化学品对人类和环境健康的潜在影响的关注大大增加。妇女的健康和环境在整个生命周期（轮）计划在罗切斯特医学中心（URMC）的大学将培训初级教师进行杰出的跨学科研究，这将有助于确定环境代理人，可以在生命的各个阶段对妇女的健康产生不利影响，从而解决这些问题。这项研究的结果将为风险评估和适当的监管提供坚实的基础，从而减少对公众健康的风险。

DESCRIPTION (provided by applicant): Concerns about the potential impacts of environmental chemicals on human and environmental health have increased greatly in the past 10 years. Through their effects on hormonal pathways, environmental chemicals can differentially affect females, particularly at critical and sensitive periods across the lifespan. These critical periods include stages of particular vulnerability (such as fetal development and among the elderly), major life transitions (such as during midlife and into late life), and stages of rapid cell proliferation and growth (such as during fetal development, puberty, and lactation). The Women's Health and Environment across the Entire Lifespan (WHEEL) program at the University of Rochester Medical Center (URMC) has as its focus interdisciplinary research specific to the intersection of: women's health, environment and health issues specific to life stages. It will build on graduate training programs already in place at URMC and complement these with educational training and research experiences designed to meet the needs of scholars within the program. This program will train Interdisciplinary Women's Health Research (IWHR) scholars from a spectrum of disciplines and ultimately promote research and translation of findings that will benefit the health of women, particularity in the area of women's environmental health across the lifespan. Our long term objectives are to: 1) "graduate" scholars who go on to successful careers in interdisciplinary research in women's environmental health; 2) establish a successful and sustainable training program in women's health research; 3) create an environment at URMC conducive to interdisciplinary research in women's health, 4) develop researchers who provide positive feedback to the research environment and the fields of women's health research, and 5) build in continuing mechanisms to effectively translate results of women's health research to health professionals and the broader community. PUBLIC HEALTH RELEVANCE: Public and scientific concerns about the potential impacts of environmental chemicals on human and environmental health have increased greatly in the past 10 years. The Women's Health and Environment across the Entire Lifespan (WHEEL) program at the University of Rochester Medical Center (URMC) will train junior faculty to conduct outstanding interdisciplinary research that will help identify environmental agents that can adversely affect women's health at all stages of life, thus addressing these concerns. Results of this research will provide a strong foundation for risk assessment and regulation, when appropriate, thus decreasing risks to public health.