Animal Behavior & Neurophysiology

项目概述：URMC动物行为和神经生理学(ABN)核心将提供IDDRC 能够利用专业知识在啮齿动物模型中进行行为和神经生理学分析的成员 并允许对IDDS的神经基础进行调查。核心的 动物行为和神经生理学的组成部分已经是IDDRC正在进行的工作的核心 调查人员，提供对当前最重要的设备、技术和分析的访问 神经科学研究。通过提供对IDD研究至关重要的成熟的分析方法， 核心的动物行为部分使研究人员能够将基因、细胞和电路的变化联系起来 动物模型中水平的行为，可能提供对IDDS的机械性洞察。同样，通过提供 获得单个神经元、多个单位和群体活动测量，这是 CORE使研究人员能够进一步建立桥梁，将神经元活动模式的变化与 行为改变可能是许多IDDS的基础。核心的两个组成部分都继续 推进和验证新技术；这两者对研究项目也是至关重要的。荷兰银行的核心将是 在专职行政和技术教职员工的支持下，提供设计方面的关键专业知识， 实施和分析对IDD研究至关重要的行为和神经生理学分析。至 为了实现这一目标，提出了三个目标。目标1是提供对资源的重要访问(包括设备和 进行对IDDRC调查者研究至关重要的行为和神经生理分析。 目标2将提供技术和方法指导和支持，以生成行为和 神经生理学分析对IDDRC调查者研究至关重要。AIM 3将提供分析和统计数据 指导和支持解释对IDDRC至关重要的行为和神经生理分析数据 调查员研究。总体而言，市建局IDDRC的ABN核心将允许调查人员执行 动物模型中的行为和神经生理学分析以了解神经基础 IDDS。通过与IDDRC其他核心的互动，它将推进确定 在细胞、神经生理和行为水平上的干预和治疗。

Project Summary: The URMC IDDRC Animal Behavior and Neurophysiology (ABN) Core will provide IDDRC members with access to behavioral and neurophysiological assays in rodent models that harness the expertise of the Core leadership and allow for investigation of the neural underpinnings of IDDs. The Core’s Components in animal behavior and neurophysiology are already central to work being conducted by IDDRC investigators, providing access to equipment, techniques, and analyses that are central to current neuroscience research. By providing access to well established assays that are essential to IDD research, the animal behavior component of the Core allows investigators to relate changes at the gene, cell, and circuit level in the animal models to behaviors that may provide mechanistic insight into IDDs. Similarly, by providing access to single neuron, multiunit, and population activity measures, the neurophysiology component of the core allows investigators to further establish bridges that link changes in patterns of neuronal activity to behavioral changes that may underlie a number of IDDs. Both components of the Core have continued to advance and validate new technologies; both are also critical to the Research Project. The ABN Core will be supported by dedicated administrative and technical faculty and staff to provide critical expertise in the design, implementation, and analysis of both behavioral and neurophysiological assays critical to IDD research. To achieve this, three Aims are proposed. Aim 1 is to provide vital access to resources (both equipment and expertise) for carrying out behavioral and neurophysiological assays critical to IDDRC investigator research. Aim 2 will provide technical and methodological guidance and support to generate data in both behavioral and neurophysiological assays critical to IDDRC investigator research. Aim 3 will provide analysis and statistical guidance and support to interpret data in both behavioral and neurophysiological assays critical to IDDRC investigator research. Collectively, the ABN Core of the URMC IDDRC will allow investigators to perform behavioral and neurophysiological assays in animal models to gain insight into the neural underpinnings of IDDs. Through its interactions with other IDDRC Cores, it will advance the long-term goal of identifying interventions and treatments at the cellular, neurophysiological, and behavioral levels.