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Animal Behavior & Neurophysiology

动物行为

基本信息

批准号：
10445286
负责人：
Deborah A Cory-Slechta
金额：
$ 18.45万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10445286
关键词：
Affect Animal Behavior Animal Model Behavior Behavioral Behavioral Assay Biological Assay Cells Cognition Complex Analysis Computer software Consultations Data Data Collection Development Ensure Equipment Faculty Generations Genes Goals Individual Infrastructure Intellectual and Developmental Disabilities Research Centers Intervention Investigation Laboratories Laboratory Research Leadership Link Measures Methodology Methods Neurons Neurosciences Research Phase Play Population Protocols documentation Reproducibility Research Research Personnel Research Project Grants Resources Rodent Model Sensory Social Behavior Techniques Training Universities Work analytical method behavioral study design experimental study insight large datasets medical schools member morris water maze neuronal patterning neurophysiology new technology relating to nervous system social theories

项目摘要

Project Summary: The URMC IDDRC Animal Behavior and Neurophysiology (ABN) Core will provide IDDRC members with access to behavioral and neurophysiological assays in rodent models that harness the expertise of the Core leadership and allow for investigation of the neural underpinnings of IDDs. The Core’s Components in animal behavior and neurophysiology are already central to work being conducted by IDDRC investigators, providing access to equipment, techniques, and analyses that are central to current neuroscience research. By providing access to well established assays that are essential to IDD research, the animal behavior component of the Core allows investigators to relate changes at the gene, cell, and circuit level in the animal models to behaviors that may provide mechanistic insight into IDDs. Similarly, by providing access to single neuron, multiunit, and population activity measures, the neurophysiology component of the core allows investigators to further establish bridges that link changes in patterns of neuronal activity to behavioral changes that may underlie a number of IDDs. Both components of the Core have continued to advance and validate new technologies; both are also critical to the Research Project. The ABN Core will be supported by dedicated administrative and technical faculty and staff to provide critical expertise in the design, implementation, and analysis of both behavioral and neurophysiological assays critical to IDD research. To achieve this, three Aims are proposed. Aim 1 is to provide vital access to resources (both equipment and expertise) for carrying out behavioral and neurophysiological assays critical to IDDRC investigator research. Aim 2 will provide technical and methodological guidance and support to generate data in both behavioral and neurophysiological assays critical to IDDRC investigator research. Aim 3 will provide analysis and statistical guidance and support to interpret data in both behavioral and neurophysiological assays critical to IDDRC investigator research. Collectively, the ABN Core of the URMC IDDRC will allow investigators to perform behavioral and neurophysiological assays in animal models to gain insight into the neural underpinnings of IDDs. Through its interactions with other IDDRC Cores, it will advance the long-term goal of identifying interventions and treatments at the cellular, neurophysiological, and behavioral levels.

项目概述：URMC IDDRC动物行为和神经生理学（ABN）核心将提供IDDRC 成员可以在啮齿动物模型中进行行为和神经生理学分析，核心领导层，并允许调查IDDs的神经基础。该芯体的动物行为和神经生理学的组成部分已经是IDDRC正在进行的工作的核心调查人员，提供设备，技术和分析，是当前的核心，神经科学研究。通过提供对碘缺乏病研究至关重要的成熟测定方法，核心的动物行为部分允许研究人员将基因、细胞和回路的变化联系起来水平的动物模型的行为，可能提供机制的IDDs的见解。同样，通过提供获得单个神经元，多单位和群体活动的措施，神经生理学的组成部分，核心使研究人员能够进一步建立连接神经元活动模式变化的桥梁，行为变化可能是一些IDDs的基础。核心的两个组成部分继续推进和验证新技术;两者对研究项目也至关重要。ABN核心将是在专门的行政和技术教师和工作人员的支持下，为设计提供关键的专业知识，实施和分析对IDD研究至关重要的行为和神经生理学测定。到为此，提出了三个目标。目标1是提供获取资源的重要途径（包括设备和专业知识），用于进行对IDDRC研究者研究至关重要的行为和神经生理学测定。目标2将提供技术和方法指导和支持，以生成行为和对IDDRC研究者研究至关重要的神经生理学测定。目标3将提供分析和统计在对IDDRC至关重要的行为和神经生理学测定中解释数据的指导和支持调查员研究。总的来说，URMC IDDRC的ABN核心将允许研究者执行在动物模型中进行行为和神经生理学测定，以深入了解 IDDs.通过与其他IDDRC核心的互动，它将推进识别在细胞、神经生理学和行为水平上的干预和治疗。