Animal Behavior & Neurophysiology

项目概述：URMC IDDRC动物行为和神经生理学（ABN）核心将提供IDDRC 成员可以利用专业知识进行啮齿动物模型的行为和神经生理学分析 核心领导层，并允许调查IDDs的神经基础。该芯体的 动物行为和神经生理学的组成部分已经是IDDRC正在进行的工作的核心 调查人员，提供设备，技术和分析，是当前的核心， 神经科学研究。通过提供对碘缺乏病研究至关重要的成熟测定方法， 核心的动物行为部分允许研究人员将基因、细胞和回路的变化联系起来 水平的动物模型的行为，可能提供机制的IDDs的见解。同样，通过提供 获得单个神经元，多单位和群体活动的措施，神经生理学的组成部分， 核心使研究人员能够进一步建立连接神经元活动模式变化的桥梁， 行为变化可能是一些IDDs的基础。核心的两个组成部分继续 推进和验证新技术;两者对研究项目也至关重要。ABN核心将是 在专门的行政和技术教师和工作人员的支持下，为设计提供关键的专业知识， 实施和分析对IDD研究至关重要的行为和神经生理学测定。到 为此，提出了三个目标。目标1是提供获取资源的重要途径（包括设备和 专业知识），用于进行对IDDRC研究者研究至关重要的行为和神经生理学测定。 目标2将提供技术和方法指导和支持，以生成行为和 对IDDRC研究者研究至关重要的神经生理学测定。目标3将提供分析和统计 在对IDDRC至关重要的行为和神经生理学测定中解释数据的指导和支持 调查员研究。总的来说，URMC IDDRC的ABN核心将允许研究者执行 在动物模型中进行行为和神经生理学测定，以深入了解 IDDs.通过与其他IDDRC核心的互动，它将推进识别 在细胞、神经生理学和行为水平上的干预和治疗。

Project Summary: The URMC IDDRC Animal Behavior and Neurophysiology (ABN) Core will provide IDDRC members with access to behavioral and neurophysiological assays in rodent models that harness the expertise of the Core leadership and allow for investigation of the neural underpinnings of IDDs. The Core’s Components in animal behavior and neurophysiology are already central to work being conducted by IDDRC investigators, providing access to equipment, techniques, and analyses that are central to current neuroscience research. By providing access to well established assays that are essential to IDD research, the animal behavior component of the Core allows investigators to relate changes at the gene, cell, and circuit level in the animal models to behaviors that may provide mechanistic insight into IDDs. Similarly, by providing access to single neuron, multiunit, and population activity measures, the neurophysiology component of the core allows investigators to further establish bridges that link changes in patterns of neuronal activity to behavioral changes that may underlie a number of IDDs. Both components of the Core have continued to advance and validate new technologies; both are also critical to the Research Project. The ABN Core will be supported by dedicated administrative and technical faculty and staff to provide critical expertise in the design, implementation, and analysis of both behavioral and neurophysiological assays critical to IDD research. To achieve this, three Aims are proposed. Aim 1 is to provide vital access to resources (both equipment and expertise) for carrying out behavioral and neurophysiological assays critical to IDDRC investigator research. Aim 2 will provide technical and methodological guidance and support to generate data in both behavioral and neurophysiological assays critical to IDDRC investigator research. Aim 3 will provide analysis and statistical guidance and support to interpret data in both behavioral and neurophysiological assays critical to IDDRC investigator research. Collectively, the ABN Core of the URMC IDDRC will allow investigators to perform behavioral and neurophysiological assays in animal models to gain insight into the neural underpinnings of IDDs. Through its interactions with other IDDRC Cores, it will advance the long-term goal of identifying interventions and treatments at the cellular, neurophysiological, and behavioral levels.