2010 Microbial Stress Response Gordon Research Conference

描述(由申请人提供)：本提案请求部分支持将于2010年7月18-23日在马萨诸塞州南哈德利的芒特霍利奥克学院举行的2010年微生物应激响应戈登研究会议。这次非常成功的两年一次的会议吸引了来自生物和物理科学的不同科学家，他们对细菌用来感知和应对各种形式的压力的机制产生了广泛的兴趣。2010年会议将有力地代表病原体的应激反应，以及生态学和生物技术背景下的应激反应。与抗菌剂相关的应激反应，包括它们的作用机制和耐药性，将是一个主要主题。除了专门讨论抗生素压力和生存的会议外，其他会议的许多演讲将涉及抗菌剂和相关毒素的各个方面。应激反应的计算和系统层面的方法也将在不同的会议中得到很好的阐述和整合。除了被邀请的演讲者外，还将从提交的摘要中挑选演讲者进行简短的演讲。这将为年轻科学家提供展示他们工作的机会。主办方还致力于发扬本次会议的特点--多样性的强大传统，并将努力让妇女和代表性不足群体的成员作为发言者和参与者。这次会议将通过整合前沿、遗传学、分子和计算方法来研究微生物系统及其应激反应，从而在推进微生物研究方面发挥战略作用。这次会议提供了一个无与伦比的场所，将来自不同学科的科学家聚集在一起，目的是揭示在压力环境中管理微生物生存和适应的主要因素。应激反应是病原体定植寄主、启动毒力程序和抵抗抗菌治疗的关键。因此，这次会议激发的洞察力和新方向将有助于社区开发新的方法来对抗病原体，改善人类健康。更好地了解微生物用来生存和适应压力的机制，将为病原体能够在人类身上定居并导致疾病，并抵抗抗菌素治疗的手段提供关键的见解。这将有助于设计抗击感染和疾病传播的新药和治疗战略。

DESCRIPTION (provided by applicant): This proposal requests partial support for the 2010 Microbial Stress Response Gordon Research Conference to be held July 18-23, 2010 at Mount Holyoke College, South Hadley, MA. This extraordinarily successful biannual conference attracts diverse scientists from the biological and physical sciences with broad interests in the mechanisms that bacteria employ to sense and respond to various forms of stress. The 2010 conference will have a strong representation of stress responses of pathogens as well as stress in the context of ecology and biotechnology. Stress responses associated with antimicrobials, both their mechanisms of action and resistance, will be a major theme. In addition to a session devoted to antibiotic stress and survival, numerous talks in other sessions will cover aspects of antimicrobials and related toxins. Computational and systems-level approaches to stress-responses will also be well represented and integrated throughout various sessions. In addition to the invited speakers, speakers will be selected for short talks from submitted abstracts. This will provide an opportunity for young scientists to present their work. The organizers are also committed to the strong tradition of diversity that has characterized this meeting and will work to include women and members of underrepresented groups as speakers and participants. This meeting will play a strategic role in advancing microbial research by integrating cutting edge, genetic, molecular, and computational approaches to the study of microbial systems and their stress responses. The meeting provides an unparalleled venue to bring together scientists from diverse disciplines with the aim of uncovering the principals governing microbial survival and adaptation in stressful environments. Stress responses are critical for pathogens to colonize hosts, initiate virulence programs, and resist antimicrobial treatments. Thus, the insights and new directions stimulated by this meeting will help the community to develop new methods to fight off pathogens and improve human health. A better understanding of the mechanisms that microbes use to survive and adapt to stress will provide key insights into the means by which pathogens are able to colonize and cause disease in humans, and resist antimicrobial treatments. This will aid in the design of new drugs and therapeutic strategies for combating infection and the spread of disease.