Microbial Pathogenesis and Genomics

描述（由申请人提供）：本申请是我校细菌学T32培训项目的第一次竞争性更新，目前每年支持3名博士预科生和1名博士博士后。我们的项目以宾夕法尼亚大学和费城儿童医院为基础，包括10个实验室，由知名的主要研究人员领导，位于一个相邻的校园里。这个项目使我们能够从宾大的人才库中招募到一些最优秀、最聪明的学员，宾大的学生和博士后有大量的微生物实验室可供选择。这个项目有组织的培训任务帮助我们作为一个群体更有效地合作和互动：与我们的第一次申请不同，我们的培训师现在有几个联合NIH资助，越来越多的联合出版物，以及一个涉及我们学员的合作网络。与四年前相比，我们的项目有5名新的培训师，随着几名新的助理教授建立他们的研究项目，不久的将来可能会增加更多的培训师。我们在微生物学项目中的研究进展会议和研讨会帮助促进了细菌发病机制、微生物免疫发病机制和细菌宏基因组学方面令人兴奋的合作工作的快速发展，并得到了机构对深度测序设施、生物信息学和无菌小鼠核心的支持，在这些努力中发挥着重要作用。由于我们越来越重视基因组方法和技术，我们已将课程名称更新为微生物发病机理和基因组学培训，以便通过包括微生物基因组学研究更准确地反映其广度。这个快速发展的领域一直是我们最近最好的三位博士预科生和一位博士预科毕业生选择的项目的重点他现在是华盛顿大学杰夫·戈登的博士后研究员。鉴于此，我们修改了培训计划，以适应对微生物基因组学感兴趣的学员，增加了新的导师、课程和培训活动。迄今为止，共有来自7个不同实验室的12名学员得到了该T32的支持，其中包括5名博士生，4名医学博士/博士。博士生3名，博士后3名。在我们的学员中，7/12是女性，3/12是代表性不足的少数民族。培训师提供的研究机会，加上强有力的机构承诺和广泛而组织良好的培训计划，将继续为学生和博士后提供微生物发病机理和基因组学方面的优秀培训。

DESCRIPTION (provided by applicant): This application represents the first competitive renewal for our Training in Bacteriology T32 program that currently supports 3 predoctoral and 1 Ph.D. postdoctoral trainees per year. Our program, which is based at the University of Pennsylvania and Children's Hospital of Philadelphia, includes 10 laboratories directed by well established principle investigators located on a single contiguous campus. This program has allowed us to recruit some of the best and brightest trainees from among a talented pool at Penn where students and post-docs have a very large number of microbiology labs to choose among. The organized training mission of this program has helped our efforts to collaborate and interact more effectively as a group: unlike our first application, our trainers now have several joint NIH grants, a growing number of joint publications, and a network of collaborations that involve our trainees. Compared to four years ago, our program has five new trainers with more likely to be added in the near future as several new assistant professors establish their research programs. Our research in progress meetings and seminars within the microbiology program have helped spur the rapid growth of exciting, collaborative work in bacterial pathogenesis, microbial immunopathogenesis, and bacterial metagenomics, with institutional support for deep-sequencing facilities, bioinformatics, and a germ-free mouse core playing important roles in these efforts. Because of our increasing emphasis on genomic approaches and technologies, we have updated the title of our program to Training in Microbial Pathogenesis and Genomics to more accurately reflect its breadth by including microbial genomic studies. This rapidly evolving area has been the focus of the projects chosen by three of our best recent predoctoral trainees as well as one of our predoctoral graduates who is now a postdoctoral fellow with Jeff Gordon at Washington University. In light of this, we have modified our training program to accommodate trainees who are interested in microbial genomics, adding new mentors, courses, and training activities. To date, a total of 12 trainees from 7 different laboratories have been supported by this T32, including 5 Ph.D. students, 4 M.D./Ph.D. students and 3 Ph.D. postdoctoral fellows. Of our trainees, 7/12 are been women and 3/12 are under-represented minorities. The research opportunities provided by the trainers coupled with strong institutional commitment and an extensive and well-organized training program will continue to provide excellent training in microbial pathogenesis and genomics to both students and postdoctoral fellows.