2010 Bacterial Cell Surfaces Gordon Research Conference

描述（由申请人提供）：本提案为第19届细菌细胞表面戈登会议寻求支持，该会议将于2010年6月27日至7月2日在新罕布什尔州新伦敦的科尔比-索耶学院举行。会议重点讨论细菌包膜和表面的生物发生、结构和功能，包括细菌膜、细胞壁、表面附属物和聚合物。本次会议在主题、模型系统和结合生物化学、分子遗传学、结构生物学、生物物理学、成像和建模的方法方面提出了多样化的方案。将有9场会议，主题涉及：1)肽聚糖细胞壁，2)外膜，3)信号传感和转导，4)细胞形态发生，5)细胞包膜应激和周质，6)蛋白质定位和分泌，7)微生物群落和抗生素，8)运输，9)细胞外细胞器和表面结构。本次会议的目标是：1)通过汇集不同群体的科学家，在方法、专业知识、实验模型和资历方面，展示这些领域最新和最令人兴奋的研究；2)产生新的想法，并促进这一多样化研究群体之间的知识交流；3)为研究生和博士后提供机会，以简短的演讲或海报形式展示他们的工作，并与该领域的领导者进行互动。戈登研究会议的传统形式，在下午和晚上安排讨论会议和非正式聚会的机会，传达了一种学院氛围，与会者之间的互动很容易达到。虽然所介绍的科学本质上是基础的，但这次多层面会议的主题对生物医学界在发病机制、抗生素作用和耐药性以及宿主-微生物相互作用等领域具有实际意义，因为许多这些现象涉及膜、细胞壁和细胞表面水平的过程。因此，这次会议将为疫苗和抗菌战略的未来发展提供一个平台。

DESCRIPTION (provided by applicant): This proposal seeks support for the 19th Bacterial Cell Surfaces Gordon Conference, which will be held from June 27 to July 2, 2010 at Colby-Sawyer College in New London, New Hampshire. The meeting focuses on the biogenesis, structure and function of bacterial envelopes and surfaces, including bacterial membranes, cell walls, and surface appendages and polymers. This conference presents a diverse program in topics, model systems, and approaches combining biochemistry, molecular genetics, structural biology, biophysics, imaging and modeling. There will be 9 sessions on topics related to 1) peptidoglycan cell walls, 2) outer membranes, 3) signal sensing and transduction, 4) cell morphogenesis, 5) cell envelope stress and periplasm, 6) protein localization and secretion, 7) microbial communities and antibiotics, 8) transport, and 9) extracellular organelles and surface structures. The objectives of this conference are to: 1) present the latest and most exciting research in these areas by bringing together a diverse group of scientists with respect to approaches, expertise, experimental model, and seniority; 2) generate new ideas and stimulate intellectual exchange between this diverse group of investigators; and 3) provide opportunities for graduate students and postdoctoral fellows to present their work in short-talk or poster format and to interact with leaders in the field. The traditional format of the Gordon Research Conferences, with programmed discussion sessions and opportunities for informal gatherings in the afternoons and evenings, conveys a collegial atmosphere where interactions between attendees are easily attained. Although the science presented is basic in nature, the topics of this multi- faceted conference are of practical interest to the biomedical community in the areas of pathogenesis, antibiotic action and resistance, and host-microbe interactions, as many of these phenomena involve processes at the level of membranes, cell walls and cell surface. This conference will thus provide a platform for future developments of vaccine and antibacterial strategies. The overall theme of the conference is the structure, function and biogenesis of the bacterial cell envelope and surface, which are intimately associated with bacterial pathogenesis as well as resistance to major antibacterial agents. This conference will bring prominent and junior scientists together to present their latest research and to spur collaboration and exchange of ideas and knowledge in a conducive environment.