Predoctoral Training Program in Genetics

描述（由申请人提供）：本提案为NIH继续支持耶鲁大学遗传学跨部门培训计划（TPG）的博士前培训。2010-2011年，TPG有30名研究生，其中14名（1至3年级）目前由NIH遗传学博士前培训资助。该项目由两位联合主任克里斯汀·雅各布斯-瓦格纳和瓦莱丽·赖因克以及一个由7名代表耶鲁大学遗传学研究界的教员组成的执行委员会监督。来自文理学院（FAS）和耶鲁医学院的73名教员作为培训师参与了该项目。主要的管理和培训机构在三个系内：耶鲁医学院的遗传学系和FAS的分子、细胞和发育生物学（MCDB）以及生态和进化生物学（EEB）系。该计划提供现代遗传学各个方面的培训，包括临床遗传学，DNA修复和癌症遗传学，基因组学和生物信息学，微生物遗传学，发育遗传学，免疫遗传学，以及进化和群体遗传学。所有被录取的学生都至少有相关领域的学士学位，并通过申请进入耶鲁大学生物和生物医学科学跨部门项目（BBS）或EEB项目。该计划有两项重大改进。从2012年秋季开始，这些学生将在第一年获得耶鲁大学的全部制度支持（津贴、学费和健康福利），其中包括正式的课程学习和三次研究轮转。一门强调定量方法的现代遗传与基因组分析新课程已被设计，并将于春季学期开课。在第一学年结束时，学生从参与TPG的教师中选择一位博士导师。第二年包括深入的研究，课程作业和资格考试，包括书面和口头部分。遗传学培训计划还包括学生组织的年度研讨会，内部研究进展系列研讨会和各种讲习班。所有学生至少经历一年的监督教学，并获得旅行资金参加并在国家或国际科学会议上展示他们的工作。除论文委员会外，所有TPG的学生都由TPG的董事指导。大多数毕业生继续在学术和研究机构或生物技术和制药公司担任领导职务。考虑到新机构对第一年的支持，我们申请者的质量和深度，以及我们目前在遗传学方面的培训优势，我们要求资金支持16名2至3年级的研究生，为期5年。

DESCRIPTION (provided by applicant): This proposal is for continued NIH support for predoctoral training within the interdepartmental Training Program in Genetics (TPG) of Yale University. For 2010-2011, there are 30 TPG graduate students, of which 14 (in years 1 to 3) are currently supported by the NIH predoctoral training grant in Genetics. The program is overseen by two co-Directors, Christine Jacobs- Wagner and Valerie Reinke, and an executive committee of 7 faculty members representing a cross-section of the genetics research community at Yale. Seventy-three faculty from departments of the Faculty of Arts and Sciences (FAS) and the Yale Medical School are involved in the program as trainers. The principal administrative and training entities are within three departments: the department of Genetics at the Yale Medical School and the departments of Molecular, Cellular and Developmental Biology (MCDB) and Ecology and Evolutionary Biology (EEB) in the FAS. The program offers training in all aspects of modern genetics, including clinical genetics, DNA repair and cancer genetics, genomics and bioinformatics, microbial genetics, developmental genetics, immunogenetics, and evolutionary and population genetics. All students admitted to the program have at least a Bachelor's degree in a relevant field and enter via application to the Yale interdepartmental program in Biological and Biomedical Sciences (BBS) or to the EEB program. Two major improvements have been made to the program. Starting Fall 2012, the students will receive full institutional support (stipend, tuition and health benefits) from Yale during their first year, whih includes formal course work and three research rotations. A new course in modern genetic and genome analysis, with emphasis on quantitative methods, has been designed and is now available during the spring semester. At the end of year 1, students select a doctoral advisor from the pool of participating TPG faculty. Year 2 consists of intensive research, course work, and the qualifying examination, which has written and oral components. The Training Program in Genetics also features a student-organized annual symposium, an in-house research-in-progress seminar series, and various workshops. All students experience at least one-year of supervised teaching and receive travel funds to attend and present their work at national or international scientific meetings. All TPG students are mentored by the TPG directors, in addition to their thesis committee. The majority of graduates go on to leading positions in academic and research institutions or in biotechnology and pharmaceutical companies. Given the new institutional support for the first year, the quality and depth of our pool of applicants, and the strengths of our current training in Genetics, we request funds to support 16 graduate students in years 2 to 3 for a five-year period.