The Next Step in Aging Research: From Bench to Bedside

描述（由申请人提供）：随着人口老龄化，糖尿病、心血管疾病、痴呆和癌症等与年龄相关的疾病的社会影响和成本将显著增加。基础衰老研究最初集中在描述衰老的特征，最近则集中在调节寿命的机制上。目前正在采取初步措施，主要是在寿命方面采取干预措施。基础生物学家和临床老年病学家之间几乎没有交流。老年医学的临床研究更侧重于功能和虚弱。考虑到老年人数量的增加和医疗保健系统面临的巨大经济压力，将我们对寿命机制的理解从长凳上转化为床边的重大进展是巨大的。老龄化研究需要扩大到包括翻译的努力，以加强对干预措施的重点，增加健康寿命和功能，而不仅仅是寿命。我们提议召开一次为期三天的会议，以提供一个论坛，讨论我们如何能够开始将衰老基础生物学中有希望的最新发现转化为临床相关的治疗策略，以增加健康寿命。本次会议将开始促进基础研究人员和临床研究人员之间的互动过程，这些研究人员专注于开发增加健康寿命、延缓虚弱以及延长寿命的干预措施。会议将通过创建一个框架，通过以下具体目标促进基础科学家和临床医生之间的翻译和合作，从而开创新局面：1）提供一个论坛，概述衰老基础生物学的发现，并讨论它们如何与临床实践相关，2）促进基础研究从业人员和临床老年病学家之间的联系，3）促进成熟的研究者与年轻的研究者（包括基础科学家和临床医生）的互动。所讨论的主题将与转化研究相关：细胞衰老，动物模型，治疗靶点，虚弱和临床需求。 公共卫生相关性：随着人口老龄化，糖尿病、心血管疾病、痴呆症和癌症等与年龄有关的疾病的社会影响和成本将显著增加。考虑到医疗保健系统的经济压力，老年人数量的增加以及我们对寿命机制的理解的实质性进展，将研究结果从板凳上转化到床边的需求是压倒性的。我们提议召开一次为期三天的会议，提供一个论坛，讨论如何将衰老基础生物学中最新的有希望的发现转化为治疗策略，以增加可能进入临床的健康寿命。

DESCRIPTION (provided by applicant): As the population ages, the societal implications and costs of age-related diseases such as diabetes, cardiovascular disease, dementias, and cancer will increase significantly. Basic aging research was initially focused on describing features of aging and more recently on mechanisms modulating lifespan. Initial steps towards interventions are being taken, mainly with respect to lifespan. There has been little communication between basic biologists and clinical geriatricians. Clinical geriatric research has been much more focused on function and frailty. The need to translate the substantial recent advances in our understanding of mechanisms of lifespan from the bench to the bedside is immense given increasing numbers of older people and huge economic strains on the health care system. Aging research needs to be expanded to encompass a translational effort to enhance focus on interventions that increase healthspan and function, rather than lifespan alone. We propose a three day meeting to provide a forum to discuss how we can begin the process of translating promising recent findings in the basic biology of aging into clinically relevant therapeutic strategies to increase healthspan. This meeting will begin the process of facilitating interactions among basic researchers and clinical investigators who are focused on developing interventions for increasing healthspan, delaying frailty, as well as enhancing lifespan. The meeting will break new ground by creating a framework to facilitate translation and collaboration between basic scientists and clinicians through the following specific aims: 1) To provide a forum to outline findings in the basic biology of aging and discuss how they might relate to clinical practice, 2) To foster links between basic research practitioners and clinical geriatricians, and 3) To facilitate interaction of established investigators with young investigators, both basic scientists and clinicians. Topics addressed will be relevant to translational research: cellular senescence, animal models, therapeutic targets, frailty, and clinical needs. PUBLIC HEALTH RELEVANCE: As the population ages, the societal implications and costs of age-related diseases such as diabetes, cardiovascular disease, dementias, and cancer will significantly increase. The need to translate findings from the bench to the bedside is overwhelming given economic strains on the health care system, increasing numbers of older people, and the substantial advances in our understanding of mechanisms of lifespan. We propose a three day meeting that provides a forum to discuss how promising recent findings in the basic biology of aging can be translated into therapeutic strategies to increase healthspan that may potentially be moved into the clinic.