2010 Immunochemistry and Immunobiology Gordon Research Conference

描述（由申请人提供）：可能没有任何器官比免疫系统对人体健康的影响更大。免疫系统的细胞几乎在身体的每个部位巡逻，以抵御病原体。然而，免疫功能失调可能发生，并可能导致免疫缺陷、自身免疫或过敏。在过去的几十年里，我们看到了关于免疫系统正常功能、免疫反应如何出错以及免疫调节如何用于治疗优势等方面知识的爆炸式增长。自1966年以来，戈登免疫化学和免疫生物学研究会议（GRC）定期举行。下一次会议计划于2010年5月在瑞士的Les diableet举行。GRC组织的理念帮助塑造了这个长期会议系列的独特特征，它由几个重要因素区分开来。首先，这是一个有声望的会议，吸引了该领域最有成就的研究人员。这并不以牺牲初级研究人员为代价，他们也作为特邀演讲者在项目中有很好的代表。其次，这是一个相对较小的会议（少于150人），在一个亲密的环境中举行，与会者呆在会议地点。此外，在戈登会议上，受邀的演讲者预计将在整个会议期间留下，他们的费用报销取决于遵守这一政策。参加整个会议的地点和道德允许初级调查员和他们的高级同事之间密切接触。第三，九个半天的会议涵盖了免疫学的广泛领域，重点是研究最深入的“热点”问题。其他广泛涉及免疫学的会议非常大，而较小的免疫学会议几乎总是关注免疫发育或细胞因子等子主题。第四，非常强调未出版材料的呈现。第五，会议有一个民主的组织，有许多专家的意见，导致方案的形成。特别是积极寻求妇女和代表性不足的少数民族的参与。在此申请中，我们寻求对这一重要而有声望的会议的支持。这是美国国立卫生研究院支持召开一次会议，总结了解免疫系统的最新进展，特别是支持初级研究人员的旅行。免疫系统每天保护我们免受感染，但它也可能功能不正常，导致过敏或慢性疾病，如1型糖尿病和多发性硬化症。会议将汇集世界领先的专家，就基础研究和更多应用主题进行密切而激烈的思想、技术和概念交流，这将有助于推进该领域的知识。

DESCRIPTION (provided by applicant): There probably is no organ with a greater impact on human health than the immune system. The cells of the immune system patrol nearly every site in the body in order to defend against pathogens. Dysregulation of immune function can occur, however, and may result in immunodeficiency, autoimmunity or allergy. The last several decades have seen an explosion of knowledge regarding the normal functioning of the immune system, how immune reactions may go awry, and how immune modulation may be used for therapeutic advantage. The Gordon Research Conference (GRC) on Immunochemistry and Immunobiology has been held regularly since 1966. The next meeting is planned for May 2010, at Les Diablerets, Switzerland. The philosophy of the GRC organization has helped to shape the unique character of this longstanding meeting series, which is distinguished by several important factors. First, it is a prestigious meeting that attracts the most accomplished investigators in the field. This is not at the expense of junior investigators, who are also well represented in the program as invited speakers. Second, it is a relatively small meeting (less than 150 attendees), held in an intimate setting with attendees staying at the meeting place. Moreover, at Gordon Conferences invited speakers are expected to stay for the entire meeting and their expense reimbursements depend on abiding by this policy. The location and the ethic of attending the entire meeting allows for close contacts between junior investigators and their more senior colleagues. Third, the nine half day meeting sessions cover the broad field of immunology, focusing on the most intensely investigated "hot" issues. Other meetings that broadly cover immunology are very large, while smaller immunology meetings almost always focus on subtopics such as immune development or cytokines. Fourth, a strong emphasis is placed on the presentation of unpublished material. Fifth, the meeting has a democratic organization with input from a great many experts leading to the formation of the program. In particular, participation by women and underrepresented minorities is actively sought. In this application, we seek support for this important and prestigious conference. This is a proposal for NIH support for a meeting to summarize the latest advances in understanding the immune system, particularly to support the travel of junior investigators. The immune system protects us against infections every day, but it can also function improperly, causing allergies or chronic diseases such as type I diabetes and multiple sclerosis. The meeting will bring together leading experts in the world for an intimate and intense exchange of ideas, techniques and concepts on both basic research and more applied topics that will help to advance knowledge in the field.