SENSITIVE MEMORY TESTS FOR DIFFERENTIATING MCI SUBGROUPS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究项目是阿尔茨海默病研究中心(ADRC)拨款的一部分。这项工作的目的是确定敏感行为任务和眼球跟踪技术是否将揭示MCI患者的表现概况，从而有助于预测阿尔茨海默病的发病。 总体计划是测试60名MCI患者、60名匹配的正常对照(NC)受试者、30名阿尔茨海默病(AD)患者和30名非痴呆症(PD)帕金森病患者。所有受试者都是从ADRC临床核心招募的。每名受试者每年都要接受两项陈述性记忆任务和一项非陈述性记忆任务以及眼球跟踪的测试。我们已经成功地在这些受试者中实施了优先看任务和眼球跟踪，目前正在收集3/4年级的数据。 这项工作的一个重要贡献是，在神经系统受损较少，因此更有可能从治疗干预中受益的时候，能够比现在更早地诊断认知功能下降的MCI患者。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research project is part of an Alzheimer's Disease Research Center (ADRC) grant. The objective of this work is to of this work is to determine whether sensitive behavioral tasks, together with eye-tracking technology, will reveal a profile of performance in MCI patients that is useful in predicting the onset of Alzheimer's disease. The overall plan is to test 60 MCI patients, 60 matched normal control (NC) subjects, 30 patients with Alzheimer's Disease (AD) and a group of 30 Parkinson's Disease patients without dementia (PD). All subjects are recruited from the ADRC Clinical Core. Each subject is tested yearly on two declarative memory tasks and one nondeclarative memory task, together with eye-tracking. We have successfully administered the preferential looking task together with eye-tracking in these subjects and are currently collecting Year 3/Year 4 data. An important contribution from this work would be the ability to diagnose sooner than is now possible in MCI patients oncoming cognitive decline, at a time when the nervous system is less compromised and, accordingly, more likely to benefit from therapeutic intervention.