ASSESSMENT OF COGNITIVE FUNCTION AND RELATIONSHIP TO STRESS REACTIVITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 相当多的研究集中在糖皮质激素水平和认知表现之间的关系。在人类中，应激源或使用糖皮质激素产生的高水平皮质醇会对陈述性记忆、面孔识别记忆和工作记忆产生有害影响。然而，关于压力反应性降低对认知表现的影响的研究很少。这样的研究要么需要通过实验降低糖皮质激素水平，要么需要研究应激反应较低的人群。我们之前已经证明，与对照组相比，患有SIB的猴子的应激反应性更低。因此，他们提供了一个重要的模型，用来测试自然产生的较低的压力反应是否与认知表现的提高有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Considerable research has focused on the relationship between glucocorticoid levels and cognitive performance. In humans, high levels of cortisol produced by stressors or by administration of glucocorticoids have deleterious effects on declarative memory, face recognition memory, and working memory. However, there is little research on the impact of reduced stress reactivity on cognitive performance. Such research requires either reducing glucocorticoid levels experimentally or studying populations with lower stress reactivity. We have previously shown that monkeys with SIB have lower stress reactivity than controls. Thus, they provide an important model with which to test whether naturally-occurring lower stress responsiveness is associated with increased cognitive performance.