LENS LASER STRATEGIES FOR PRESBYOPIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：测定老年恒河猴晶状体激光治疗前后中枢刺激后的调节能力。 将电极植入2只年长恒河猴的Edinger Westphal核，以便中枢刺激调节。此外，还以4只幼龄恒河猴为实验对象，对飞秒激光进行了定标。基线测试是在确定晶状体激光对调节反应的影响之前完成的。这种飞秒激光手术似乎对猴眼有很好的耐受性。然而，在接受激光治疗的5只猴子中，有2只观察到视网膜小面积烧伤(1-2 mm)。使用哈廷格符合验光仪获得屈光测量的能力在激光24小时后开始的飞秒激光程序中没有受到影响，并且动物没有表现出异常行为或疼痛或不适的证据。这项研究使用了WNPRC Research Services。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To determine the accommodative ability in older rhesus monkeys following central stimulation before and after lens lasering. An electrode was implanted into the Edinger Westphal nucleus of each of 2 older rhesus monkeys so that accommodation could be stimulated centrally. In addition 4 young rhesus monkeys were used as test subjects to calibrate the femtosecond laser. Baseline testing was completed prior to determination of the effects of lens lasering on the accommodative response. The femtosecond laser procedure appears to be well tolerated in the monkey eye. However, small retinal burns (1-2 mm in size) were noted in 2 out of 5 monkeys lasered. The ability to obtain refractive measurements with the Hartinger coincidence refractometer was not compromised by the femtosecond laser procedure beginning 24 hours after lasering and the animals did not exhibit abnormal behavior or evidence of pain or discomfort. This research used WNPRC Research Services.