NEUROBIOLOGY OF PRIMATE SOCIAL BEHAVIOR

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目的具体目标如下： 具体目标1继续研究在两周大时接受鹅掌酸损毁杏仁核或海马区的猴子的社会情绪发育。 具体目的2评估在两周大时接受鹅掌酸损毁杏仁核或海马区的猴子的性行为和母性行为。 具体目的3采用恐惧强化惊吓和脉冲前抑制等声学惊吓任务，研究杏仁核永久性损伤和一过性失活对恐惧行为成分加工的影响。 具体目的4利用微型正电子发射计算机断层扫描技术检测成年和幼年猕猴杏仁核鹅掌酸损伤所致的脑可塑性。 具体目的5使用microPET成像技术来研究在婴儿时期接受杏仁核损伤的动物在二元社会交往中恐惧行为增加的潜在神经底物，以及患有杏仁核损伤的成年动物社会行为增加的潜在神经底物。 具体目的6利用杏仁核可逆失活的遗传方法复制杏仁核永久性损伤对社会情绪行为的影响。 具体目标7使用在当前资助期内开发的用于调查猕猴社会行为的方案来调查额叶的两个区域在社会行为中的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Specific Aims of this project are as follows: Specific Aim 1  To continue investigations of the socioemotional development of monkeys who received ibotenic acid lesions of the amygdala or hippocampus at two weeks of age. Specific Aim 2  To evaluate the sexual and maternal behavior in monkeys who received ibotenic acid lesions of the amygdala or hippocampus at two weeks of age. Specific Aim 3  To use acoustic startle tasks such as fear potentiated startle and prepulse inhibition to investigate the effect of permanent lesions and transient inactivation of the amygdala on components processes of fear behavior. Specific Aim 4  To use microPET imaging to examine brain plasticity resulting from ibotenic acid lesions of the amygdala in the adult and infant monkeys. Specific Aim 5  To use microPET imaging to investigate potential neural substrates for increased fear behavior by animals who received amygdala lesions as infants during dyadic social interactions and for increased social behavior for adult animals with amygdala lesions. Specific Aim 6  To use a genetic method for reversible inactivation of the amygdala to replicate the effects of permanent amygdala lesions on socioemotional behavior. Specific Aim 7  To use protocols developed to investigate social behavior in the macaque monkey during the current funding period to investigate the roles of two regions of the frontal lobe in social behavior.