PRODUCTION OF PEDIGREED SPF RHESUS MACAQUES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 在艾滋病相关研究中，持续需要没有特定病原体，特别是持续性病毒感染的印度血统恒河猴。我们已经成功地建立和维持了一个长期的SPF繁殖群，遗传特征为印度恒河猴。 目前的殖民地普查是302动物。到目前为止，该殖民地生产的148只动物已提供给各机构的艾滋病研究人员。 在该群体中生产的动物是猴疱疹病毒1型（CHV 1）、猿猴D型逆转录病毒（SRV）、猿猴免疫缺陷病毒（SIV）、猿猴嗜T淋巴细胞病毒（STLV）和猿猴泡沫病毒（SFV）的SPF。所有动物都有已知的血统和地理来源。还对产生的后代进行几种MHC I类（Mamu A*01、A*02、A*08、B*01、B*17）和II类（DPB、DQA、DQ B）基因座的单倍型分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is a continuing need for rhesus macaques of Indian-ancestry that are free of specific pathogens, particularly persistent viral infections, for use in AIDS-related research. We have successfully established and maintained a long-term breeding colony of SPF, genetically characterized Indian origin rhesus macaques. The current colony census is 302 animals. To date, 148 animals produced in this colony have been made available to AIDS researchers at various institutions. Animals produced in this colony are SPF for Cercopithecine herpesvirus 1 (CHV1), simian type D retrovirus (SRV), simian immunodeficiency virus (SIV), simian T- lymphotropic Virus (STLV) and simian foamy virus (SFV). All animals are of known pedigree and geographic origin. Offspring produced are also haplotyped for several MHC class I (Mamu A*01, A*02, A*08, B*01, B*17) and class II (DPB, DQA, DQB) loci.