Women's Interagency HIV Study (WIHS) IV, Chicago Consortium

描述（由申请人提供）：WIHS是一项多中心前瞻性流行病学队列研究，研究对象为1994年和2002年入组的HIV感染或HIV感染风险增加的女性。该研究的目的是继续随访WIHS队列，从而支持对美国有代表性的主要是少数民族成年女性的HIV感染自然史和治疗史的研究，以及支持对与长期HIV感染和治疗相关的新问题的研究。WIHS-IV科学倡议将包括正在进行的核心研究项目和启动新的项目，这些项目涉及抗逆转录病毒治疗反应的预测因素以及艾滋病毒感染和艾滋病毒治疗在心血管疾病、肝病、激素功能、神经认知障碍、癌症和其他发病率以及艾滋病进展和死亡方面的长期后果。此外，在WIHS-IV资助周期内，科学合作将继续扩大独立的、由科研人员驱动的研究赠款。 作为一项正在进行的队列研究，芝加哥研究中心将通过继续收集参与者的高质量数据和标本并保持极好的队列保留率，继续支持整体WIHS科学研究议程。芝加哥中心还将在关键领域发挥领导作用，包括HIV病毒学和宿主免疫学、HIV感染的长期发病机制和治疗毒性以及病毒耐药性的影响。课程将包括丙型肝炎（HCV）和B病毒（HBV），人乳头瘤病毒（HPV）等合并感染的影响;妇女的治疗使用和治疗效果，影响艾滋病毒疾病的行为和心理社会因素，代谢异常的影响，激素因素对艾滋病毒疾病的影响;衰老和绝经对艾滋病的影响，环境和宿主遗传因素对艾滋病的相互作用;以及对WIHS参与者的大脑结构、神经认知功能和身体损伤的评估。

DESCRIPTION (provided by applicant): The WIHS is a multi-site prospective epidemiology cohort study of women enrolled in 1994 and 2002 who either are infected with HIV or are at increased risk for acquiring HIV infection. The purpose of the study is to continue follow-up of the WIHS cohort, thereby supporting studies of the natural and treated history of HIV infection in representative, primarily minority, adult women in the United States, as well as supporting studies of emerging questions related to long-term HIV infection and treatment. WIHS-IV scientific initiatives will include ongoing core research projects and the initiation of new projects on the predictors of response to antiretroviral therapy and long term consequences of HIV infection and HIV therapy in terms of cardiovascular disease, liver disease, hormonal function, neurocognitive impairment, cancer and other morbidities, as well as progression to AIDS and death. Additionally during the WIHS-IV grant cycle scientific collaborations will continue to expand independent, investigator-driven research grants. As an ongoing cohort study that, The Chicago site will continue to support the overall WIHS scientific research agenda by continuing to collect quality data and specimens from participants and maintain superb cohort retention. The Chicago site will also provide leadership for key areas of interest including HIV virology and host immunology, long term pathogenesis of HIV infection and treatment toxicities, and impact of viral resistance. Topics of study will include the effect of co-infections such as hepatitis C (HCV) and B virus (HBV), human papillomavirus (HPV); therapy use and treatment effects in women, behavioral and psychosocial factors influencing HIV disease, effects of metabolic abnormalities, impact of hormonal factors on HIV disease; the effects of aging and menopause on HIV disease, the interaction of environmental and host genetic factors on HIV disease; and the assessment of brain structure, neurocognitive functioning, and physical impairment among WIHS participants.