2012 Microbial Stress Response Gordon Research Conference

描述（由申请人提供）：本提案要求部分支持将于2012年7月15日至20日在马萨诸塞州南哈德利的蒙特霍利奥克学院举行的2012年微生物应激反应戈登研究会议。2012年微生物应激反应会议将提供一个论坛，公开报告研究单个微生物和微生物群落如何应对应激的最新进展。这个一年两次的会议传统上吸引了生物和物理科学家研究医学，环境和生物技术相关的微生物以及模式生物的压力反应，使用遗传，细胞生物学，基因组和计算技术。2012年的会议将整合会议描述尖端，遗传，分子和计算方法，从单一微生物到社区的压力反应。我们计划在2012年的会议上强调剖析压力反应的新方法的影响。例如，2012年会议是研究人员利用高通量测序和基因组技术研究社区中微生物应激反应和科学家分析纯培养物和模式生物之间深入对话的理想场所。我们希望这次对话将使所有参与者受益，为分析复杂微生物群落的研究人员提供基本的生物学见解，并向研究纯培养物的科学家通报深度测序和其他高通量技术在具有医学，环境和生物技术意义的生态系统中的进展。我们预测这次会议将增加对生物，技术和计算问题的理解，促进科学讨论，并促进研究人员在不同时间，生物体和社区尺度上研究压力反应的新合作。从许多标准来看，这次会议都非常成功，传统上有一个感兴趣的与会者的等待名单。由于社区的兴趣，微生物应激反应会议在戈登研究会议场地举行，该场地容纳约175人，可容纳约60张学生，博士后和其他研究人员的海报。它足够大，包括不同的观众，但规模和长度，允许深入讨论和与会者之间的相当大的互动。会议组织者致力于延续本次会议与会者多样性的传统，并将努力确定和吸收妇女、代表性不足的群体成员和青年科学家作为发言者或与会者。 公共卫生相关性：应激反应对于细菌生长、建立有益的微生物-宿主相互作用以及病原体定殖宿主、启动毒力程序和抵抗抗微生物处理至关重要。在这次会议上提出的新结果将帮助社区了解压力反应如何控制有益和致病微生物的活动，并制定改善人类健康的策略。美国国立卫生研究院的资金将有助于支持人口统计学上多样化的生物学家，物理科学家，工程师和计算生物学家的参与，他们在分子，社区和生态系统层面研究压力反应。

DESCRIPTION (provided by applicant): This proposal requests partial support for the 2012 Microbial Stress Response Gordon Research Conference to be held July 15-20, 2012 at Mount Holyoke College, South Hadley, MA. The 2012 Microbial Stress Response meeting will provide a forum for open reporting of recent advances from studying how individual microbes and microbial communities to respond to stress. This biannual conference traditionally attracts biological and physical scientists studying stress responses in medical, environmental, and biotechnology-relevant microbes as well as in model organisms, using genetic, cell biological, genomic and computational techniques. The 2012 meeting will integrate sessions describing cutting edge, genetic, molecular, and computational approaches to stress responses spanning from single microbes to communities. We plan to highlight the influence of new approaches to dissecting stress responses in the 2012 meeting. For example, the 2012 meeting is the perfect venue for in depth dialogue between researchers using high throughput sequencing and genomic techniques to study microbial stress responses in communities and scientists analyzing pure cultures and model organisms. We expect this dialogue will benefit all participants, providing basic biological insight to researchers analyzing complex microbial communities and informing scientists studying pure cultures of advances coming from deep-sequencing and other high throughput techniques in ecosystems of medical, environmental and biotechnological significance. We predict the conference will increase understanding of the biological, technical and computational issues, foster scientific discussions, and catalyze new collaborations among researchers studying stress responses at different temporal, organismal and community scales. This meeting is very successful by many criteria, and traditionally has a waiting list of interested attendees. Due to community interest, the Microbial Stress Response meeting is held in a Gordon Research Conference venue that houses ~175 and can accommodate ~60 posters by students, post-doc and other researchers. It is large enough to include a diverse audience but of a size and length that allows deep discussion and considerable interaction among attendees. The meeting organizers are committed to continue this meeting's tradition of participant diversity and will work to identify and include women, members of underrepresented groups and junior scientists as speakers or participants. PUBLIC HEALTH RELEVANCE: Stress responses are critical to bacterial growth, establishment of beneficial microbe-host interactions, as well as for pathogens to colonize hosts, initiate virulence programs and resist antimicrobial treatments. The new results presented at this meeting will help the community understand how stress responses control activities of beneficial and pathogenic microbes and develop strategies to improve human health. NIH funds will help support participation by a demographically diverse audience of biologists, physical scientists, engineers and computational biologists who study stress responses at the molecular, community and ecosystem levels.