Pathology and Biorepository

项目总结（见说明）： 马里兰州大学Marlene和Stewart Greenebaum癌症中心（UMCCC）的病理学和生物储存库共享服务（PBSS）有两个主要任务：（1）提供始终如一的优质库存患者样本（组织和其他制剂），同时维护患者机密性;（2）提供病理学、组织学和组织技术咨询服务，以协助临床研究者 在人类组织标本的获取、分析和临床病理学相关性方面。通过访问组织标本，研究人员可以进行分析（例如，基因组学或蛋白质组学研究）来理解正常和患病组织的生物学，然后将该知识转化用于诊断和临床应用。PBSS是唯一的组织库共享服务，用于在外科手术中取出的标本， 马里兰大学巴尔的摩分校（UMB）。PBSS与病理学系解剖病理学处有着一体化的关系，这对于获得特征良好的组织样本以及病理学和组织学专业知识至关重要。除了所有出售的肿瘤的持续银行，PBSS还提供肿瘤特异性组织采购和处理;访问超过7，000个 冷冻肿瘤样本，其中5，900个与同一患者的正常组织配对;以及访问解剖病理学实验室的福尔马林固定石蜡包埋（FFPE）标本档案，其中包括1，260，000多个具有各种病理诊断的FFPE组织块。PBSS对冷冻样本库和手术病理学档案进行搜索，以获得特定样本集， 随后由Olgaloffe博士或William Twaddell博士取回标本并确认相关病变/肿瘤的存在。根据具体的研究问题，可根据要求提供临床病理学参数。PBSS工作人员拥有广泛的技术经验 和标本类型。PBSS为病理学家提供方案制定和组织评估咨询;机构审查委员会问题;技术支持;以及研究标本的常规组织学和免疫组织化学分析，数字图像分析和组织微阵列构建的专业知识。PBSS的成功和有效性是基于其将其病理学和 生物资源和专业知识投入UMCCC正在进行的研究。

PROJECT SUMMARY (See instructions): The Pathology and Biorepository Shared Service (PBSS) at the University of Maryland Marlene and Stewart Greenebaum Cancer Center (UMGCC) has two main missions: (1) provide access to a consistently excellent quality of banked patient samples (tissue and other preparations) while maintaining patient confidentiality and (2) provide pathology, histology, and histotechnology consultation services to assist clinical investigators in the procurement, analyses, and clinicopathologic correlation of human tissue specimens. Through access to tissue specimens, investigators can perform analyses (e.g., genomic or proteomic studies) to understand the biology of normal and diseased tissues and then translate that knowledge for diagnostic and clinical applications. PBSS is the only tissue bank shared service for specimens removed at surgery at the University of Maryland-Baltimore (UMB) campus. PBSS has an integrated relationship with the Division of Anatomic Pathology of the Department of Pathology, which is essential for obtaining well-characterized tissue samples and pathology and histology expertise. In addition to the ongoing banking of all sold tumors,PBSS also provides investigator-specific tissue procurement and processing; access to more than 7,000 frozen tumor samples, of which 5,900 are paired with normal tissue from the same patient; and access to the formalin-fixed paraffin-embedded (FFPE) specimen archive of the Anatomic Pathology Laboratory, which consists of more than 1,260,000 FFPE tissue blocks with various pathologic diagnoses. PBSS performs searches of the frozen sample library and the surgical pathology archive for sets of specific samples, with subsequent retrieval of specimens and confirmation ofthe presence of relevant lesion/tumor by Drs. Olgaloffe or William Twaddell. The provision of clinicopathologic parameters is available upon request, depending on the specific research question. PBSS staff possess extensive experience with a wide range of techniques and specimen types. PBSS offers consultation with pathologists for protocol development and tissue evaluation; Institutional Review Board issues; technical support; and expertise for routine histological and immunohistochemical analyses of research specimens, digital image analysis, and tissue microarray construction. The success and effectiveness of PBSS is based on its ability to integrate its pathology and biorepository resources and expertise into research being conducted at UMGCC.