Acquisition of an Orbitrap Elite Mass Spectrometer with ETD

描述（由申请人提供）：纽约大学医学院新的蛋白质组学资源核心致力于为生物医学研究社区提供最先进的质谱技术，以促进他们的研究并改善科学基础设施。因此，我们正在申请资金，用于Thermo Fisher Scientific的电子转移解离（ETD）的Orbitrap Elite质谱仪，以实现高通量蛋白质组学研究，用于识别和定量复杂混合物中的蛋白质，蛋白质复合物的表征，翻译后修饰的映射以及蛋白质和肽的深入结构表征。我们在纽约大学和亨特学院召集了一群多学科的用户（City University of纽约），其关于癌症进展的机制的工作通过遍在蛋白途径的过度或失活、干细胞调节、DNA复制控制、转录因子调节、染色质调节、膀胱尿路上皮形成，以及使用天然来源（毒液）的药物开发将不可能没有内部最先进的质谱仪。

DESCRIPTION (provided by applicant): The new Proteomics Resource Core at the NYU School of Medicine is committed to provide the biomedical research community access to state of the art mass spectrometric technology to facilitate their research and improve the scientific infrastructure. We are therefore requesting funds for an Orbitrap Elite mass spectrometer with Electron Transfer Dissociation (ETD) from Thermo Fisher Scientific to enable high throughput proteomic studies for the identification and quantification of proteins in complex mixtures, characterization of protein complexes, mapping of post translational modifications, as well as in depth structural characterization of proteins and peptides. We have assembled a group of multidisciplinary users at NYU and at Hunter College (City University of New York) whose work on mechanisms of cancer progression through over- or inactivation of the ubiquitin pathway, stem cell regulation, DNA replication control, transcription factor regulation, chromatin regulation, bladder urothelial formation, as well as drug development using natural sources (venoms) will be impossible without an in-house state of the art mass spectrometer.