The University of Rochester Core Center for Musculoskeletal Biology and Medicine

这个P30申请，题为“罗切斯特大学肌肉骨骼生物学和医学核心中心（URCCMBM）”，旨在提供共享的设施和服务，以完善，NIH资助的研究人员在罗切斯特大学谁是解决科学问题的肌肉骨骼生物学和医学，以提高效率，加快研究步伐，并促进临床翻译。此外，通过其独特的丰富计划，旨在扩大研究基础，URCCMBM旨在促进研究助理教授（RAP）和无资金的医生科学家（UPS）在肌肉骨骼研究中心（CMSR）的发展和推广，鉴于最近基金会赠款的消失，他们对校外资金的选择有限，企业赞助的研究和大学创业包，这对他们的职业发展至关重要。URCCMBM中提出了三个核心。行政核心将监督整个计划，并运行充实计划，其中包括：试点项目（针对RAP & UPS），指导子核心，临床研究子核心，访问教授计划，旅行赠款和年度研究研讨会。组织学、生物化学和分子成像核心将促进体外转化研究（细胞和分子测定、组织学和形态测定），生物力学和全组织成像核心将促进体内转化研究（机械测试、显微CT、体内多光谱和超声成像）。URCCMBM得到了医学与牙科学院和NIH资助的CTSI的机构支持。执行委员会将每半年审查一次该计划，以确保URCCBMB实现其主要目标：提高研究效率，促进合作，导致新的NIH赠款，以及我们的RAP和UPS的职业发展。

This P30 application, entitled "The University of Rochester Core Center for Musculoskeletal Biology and Medicine (URCCMBM)," seeks to provide shared facilities and services to the well-established, NlH funded Investigators at the University of Rochester who are addressing scientific problems in musculoskeletal biology and medicine, in order to improve efficiency, accelerate the pace of research, and facilitate clinical translation. Additionally, through its unique Enrichment Program designed to expand the research base, the URCCMBM aims to facilitate the development and promotion of Research Assistant Professors (RAP) and unfunded physician-scientists (UPS) in the Center for Musculoskeletal Research (CMSR), who have limited options for extramural funding given the recent disappearance of Foundation grants, corporate-sponsored research and University start-up packages that are critical for their career advancement. Three Cores are proposed within the URCCMBM. The Administrative Core will oversee the entire program and run the Enrichment Program that includes: Pilot Projects (targeted to RAP & UPS), a Mentoring sub-Core, a Clinical Research sub-Core, a Visiting Professor Program, Travel Grants and an Annual Research Symposium. The Histology, Biochemistry and Molecular Imaging Core will facilitate in vitro-translational research (cellular and molecular assays, histology and morphometry), and the Biomechanics and Whole Tissue Imaging Core will facilitate in vivo translational research (mechanical testing, micro-CT, in vivo multispectral and ultrasound imaging). The URCCMBM is heavily leveraged by institutional support from the School of Medicine & Dentistry and the NIH funded CTSI. The Executive Committee will review the program semiannually to ensure that URCCBMB achieves its primary goals of: improved research efficiency, fostered collaborations leading to new NIH grants, and career advancement of our RAP and UPS.