The Manhattan HIV Brain Bank

描述（由申请人提供）：曼哈顿HIV脑库（MHBB）是国家神经艾滋病组织联盟（NNTC）的成员，自1998年以来一直是神经艾滋病研究界的资源。它对一群主要感染艾滋病毒的人进行神经学、神经心理学、精神病学、一般医学和尸检病理学评估，这些人同意在死亡时捐献器官，用于神经艾滋病和艾滋病研究。由于MHBB的观察性纵向研究，其组织和液体资源被密集地注释，并支持对hiv相关中枢（CNS）和外周神经系统（PNS）疾病的广泛调查。在下一个周期中，MHBB将与NNTC的其他成员一起创建一个优化的队列，用于研究面对抗逆转录病毒治疗时持续存在的hiv相关认知障碍的中枢神经系统储库、衰老和发病机制。具体而言，MHBB将增加老年人的代表性，以及那些在可变CD4最低点后稳定抑制血浆病毒载量的人。随着这一转变，MHBB将保持重要的队列特征反映

DESCRIPTION (provided by applicant): The Manhattan HIV Brain Bank (MHBB), member of the National NeuroAIDS Tissue Consortium (NNTC), has been a resource for the neuroAIDS research community since 1998. It performs neurologic, neuropsychological, psychiatric, general medical, and autopsy pathology assessments on a cohort of predominantly HIV-infected individuals, who agree to be organ donors upon demise, for the purposes of neuroAIDS and AIDS research. As a result of MHBB's observational longitudinal study, its tissue and fluids resources are densely annotated, and support a wide range of investigations into HIV-associated central (CNS) and peripheral nervous system (PNS) disorders. In the next cycle, MHBB will participate with other members of the NNTC to create a cohort optimized for the study of CNS reservoirs, aging, and pathogenesis of HIV-associated cognitive disorders persisting in the face of antiretroviral therapy. Specifically, MHBB will increase its representatin of older individuals, and those with stably suppressed plasma viral loads following variable CD4 nadirs. With this transition, MHBB will maintain important cohort characteristics reflective of the NYC epidemic, including prominent representation of minorities, women, and socio-culturally and medically complex individuals. MHBB will regularly upload clinical and pathologic information into a central consortium database, participate in all the protocol-defining and qualit assurance programs of the NNTC, and distribute its information, tissues, and fluids to investigators through central processes led by the NNTC data coordination center. MHBB will continue to analyze the behavioral and neurologic phenotypes of its cohort, to better understand how neuroAIDS disorders manifest in aging, demographically diverse individuals living through changes in therapeutic eras. Through observational studies, MHBB will better serve neuroAIDS researchers, as careful delineation of phenotype will assure better assignment of resources to research designs. Furthermore, observational study of HIV-associated CNS and PNS disease will allow MHBB to better understand neurobiologically relevant methods for subject characterization, and how to continue modifications of the cohort as the HIV epidemic continues to evolve.