ShEEP request for high-resolution flow cytometry system

此应用程序将支持购买最先进的流式细胞仪 系统（带模式控制的CytoFLEX LX流式细胞仪板加载器）， 作为一个核心的研究资源，在迈克尔E。DeBakey VA医疗中心。 该系统将增强7名VA调查员的研究计划， 他们获得高通量，高灵敏度的流式细胞术数据的研究 研究重点是与退伍军人相关的疾病，包括血栓形成、肺 疾病、癌症和败血症等。该仪器将取代16 我们的研究大楼里有一台使用了一年的流式细胞仪。的 仪器于2013年转移到研究服务线，而不是 在我们医院升级了临床流式细胞仪后被丢弃。现有 流式细胞仪已经过时，不再生产，这带来了挑战 确保及时有效的维护，这对我们的VA 研究人员虽然我们的学术分支机构有类似的流式细胞仪 近1.5英里外的核心设施中的系统， 到/从附属机构和有限的调度可用性导致使用障碍 联盟的资源在空间站上使用这些设备将 加强现有的核心研究设备在我们的设施，帮助促进 我们的VA调查人员之间的合作研究，并提供了巨大的 改善我们的整体研究计划。预计这将促进 VA调查人员之间的进一步合作，以及改善我们的努力， 为我们的医疗中心招募和留住有才能的调查人员。

This application will support the purchase of a state-of-the-art flow cytometry system, (CytoFLEX LX Flow Cytometer Plate Loader with Mode Control), to be used as a core research resource at Michael E. DeBakey VA Medical Center. This system will enhance the research program of 7 VA investigators and enable them to obtain high-throughput, high-sensitivity flow cytometry data for research studies focused on conditions relevant to Veterans including thrombosis, lung disease, cancer, and sepsis, among others. This instrument will replace a 16 year-old flow cytometer available currently in our research building. That instrument was transferred to the Research Service Line in 2013, in lieu of being discarded, after our hospital upgraded its clinical flow cytometer. The existing flow cytometer is outdated and no longer in production, which poses a challenge for securing timely and effective maintenance, which adversely impacts our VA researchers. Although our academic affiliate has comparable flow cytometry systems in core facilities nearly 1.5 miles away, the delays associated with travel to/from the affiliate and limited scheduling availability induce obstacles in using the resources at the affiliate. Having access to this equipment on station will enhance the existing core research equipment at our facility, help promote collaborative research among our VA investigators, and provide a tremendous improvement to our overall research program. This is expected to promote further collaboration among VA investigators as well as improve our efforts to recruit and retain talented investigators to our medical center.