05 Tissue Biospecimen and Pathology Resource

项目摘要：组织生物显微镜与病理学资源(TBPR) 组织生物样品和病理资源(TBPR)提供了灵活、成熟和功能良好的 与高级研究组织学核心相结合的人体组织标本机构生物储存库 支持人类和动物组织标本的组织病理学特征的设施。生物储存库 机构组织库(ITB)和研究组织学基金(RHF)是两个历史悠久、成熟、高度 功能CCSG支持的组成TBPR的共享资源。ITB是CLIA认可的机构， 为中心成员提供通过同意获得的人体组织、血液和其他液体的通道 机构审查委员会批准的方案下的患者。RHF提供常规和先进的电池-和 为调查人员提供基于组织的服务。TBPR支持整个研究领域，包括 临床试验中的生物标记物研究以及基础和临床前动物模型研究。在上一次资助期间 ITB聘请了委员会认证的病理学家助理来标准化和提高组织质量 整个机构的收藏品。这一努力继续支持新的机构倡议和战略 纵向采集组织和血液样本以获取下游分子的临床试验联盟 以及免疫简档分析和新工作流过程的相关实现。《任务规定》 主任是翻译分子病理学主席Ignacio Wistuba博士，联席主任是Stanley博士 病理和实验室医学部主任汉密尔顿和迪彭·马鲁博士， 翻译分子病理学。TBPR提供关键服务，包括：生物标本收集， 加工、配送和质量控制；独特的、专门的服务，如组织化学染色， 免疫组织化学(IHC)、组织芯片、激光捕获显微切割、原位杂交和数字化 病理学使用新获得的最先进的设备，如组织微阵列，IHC自动染色， 和Aperio幻灯片扫描仪；以及新的病理咨询服务。在上一个赠款周期中，ITB收集了 637,042个样本，RHF进行了1,069,932次手术。MD Anderson通过以下方式支持了TBPR 资本设备基金总额为1 783 014美元(ITB为385 387美元；RHF为1 397 627美元)。自从前一个授予周期以来， ITB和RHL分别支持了234名和499名癌症中心成员，使用率持平 在所有16个CCSG计划中分发。同行评议资助的研究占总使用量的80%以上， 32%(614,243美元)是在赠款Yr44中向CCSG申请的。TBPR促进了481的出版 同行评议论文，其中358篇(74%)发表在IF&>5期刊上，159篇(33%)发表在IF&>10期刊上，70篇发表在IF&>；10期刊上 (15%)在有IF&GT；20的期刊上。在下一个供资周期，TBPR将继续标准化、精简、 并优化流程，从而使设施能够提供高质量的快速服务。

PROJECT SUMMARY: TISSUE BIOSPECIMEN AND PATHOLOGY RESOURCE (TBPR) The Tissue Biospecimen and Pathology Resource (TBPR) provides a flexible, sophisticated and well-functioning institutional biorepository for human tissue specimens in conjunction with an advanced research histology core facility that supports histopathologic characterization of human and animal tissue specimens. The biorepository Institutional Tissue Bank (ITB) and the Research Histology Facility (RHF) are 2 longstanding, mature, highly functional CCSG-supported shared resources that comprise the TBPR. The ITB is a CLIA-accredited facility that provides center members with access to human tissues, blood, and other fluids obtained from consenting patients under Institutional Review Board-approved protocols. The RHF provides routine and advanced cell- and tissue-based services to investigators. The TBPR supports the entire spectrum of research studies, including biomarker studies in clinical trials as well as basic and pre-clinical animal model research. During the last funding cycle, the ITB recruited board-certified pathologists' assistants to standardize and improve the quality of tissue collection throughout the institution. This effort continues to support new institutional initiatives and strategic alliances on clinical trials for the longitudinal collection of tissue and blood specimens for downstream molecular and immune profiling analyses and the associated implementation of new workflow processes. The TBPR director is Dr. Ignacio Wistuba, chair of Translational Molecular Pathology, and the co-directors are Dr. Stanley Hamilton, head of the Division of Pathology and Laboratory Medicine, and Dr. Dipen Maru, a professor in Translational Molecular Pathology. The TBPR provides key services, including: biospecimen collection, processing, distribution, and quality control; unique, specialized services, such as histochemical stains, immunohistochemistry (IHC), tissue microarray, laser-capture microdissection, in situ hybridization, and digital pathology that utilizes newly acquired, state-of-the-art equipment such as tissue microarrayers, IHC autostainers, and Aperio slide scanners; and new pathology consultation services. Over the last grant cycle, the ITB collected 637,042 specimens, and the RHF performed 1,069,932 procedures. MD Anderson has supported the TBPR with capital equipment funds that total $1,783,014 (ITB $385,387; RHF $1,397,627). Since the previous grant cycle, the ITB and RHL have supported 234 and 499 cancer center members, respectively, and usage was evenly distributed among all 16 CCSG programs. Peer review-funded research accounts for over 80% of total usage, and 32% ($614,243) is requested from the CCSG in grant Yr44. The TBPR facilitated the publication of 481 peer-reviewed papers, including 358 (74%) in journals with IF >5, 159 (33%) in journals with IF >10, and 70 (15%) in journals with IF >20. During the next funding cycle, the TBPR will continue to standardize, streamline, and optimize processes, thereby allowing the facilities to provide high-quality expedited services.