Phenotyping Core

表型核心将为ORDRCC研究人员提供先进的高含量、尖端生物分子表型服务和数据集，涵盖遗传、基因组、蛋白质和功能性细胞生物反应，可通过临床表征和生物信息库核心(CCBC)或其他ORDRCC Investigator项目获得。ORDRCC中的表型核心和CCBC的紧密集成使表型特征的有效表现以及特定临床样本上的临床特征与分子或细胞表型的相关性得以实现。将分子或细胞表型的完整表征所需的一系列技术整合到一个核心中，使核心能够更好地协助所有ORDRCC调查人员根据他们的个别项目需求进行有效的规划/设计、执行和数据分析。该中心能够提供使用临床标本进行研究的经验，在广泛的分子和生物分析方面的必要技术专长，获得使尖端方法能够解决研究问题的设备和资源，对收集的数据进行质量控制评估，以及适合于表型/临床相关性的高端统计建模的数据处理。因此，表型核心的目标可以概括如下： 目标1：为ORDRCC研究人员提供实验项目设计、成本分析、实施规划和项目管理方面的专家咨询。 目标2：在遗传、基因组、蛋白质、免疫表型和免疫功能领域，为高通量/高含量的实验表型表征和生物标记物分析提供先进的技术、集中的设备和经验丰富的人员。 目标3：就数据质量控制、原始数据处理和为更广泛的统计建模准备数据集提供指导。 目标4：评估和开发表型表征的新尖端技术。

The Phenotyping Core will provide ORDRCC investigators with access to advanced high-content, cutting-edge biomolecular phenotyping services and datasets spanning genetic, genomic, proteomic, and functional cellular bioresponses on clinical samples available through the Clinical Characterization and Biorepository Core (CCBC) or from other ORDRCC Investigator projects. The tight integration of the Phenotyping Core and the CCBC within the ORDRCC enables both the efficient performance of phenotype characterizations and correlation of the clinical characteristics with molecular or cellular phenotypes on specific clinical samples. Consolidation of the range of technologies required for the complete characterization of a molecular or cellular phenotype into a single Core allows the Core to better assist all ORDRCC investigators in the efficient planning/design, execution and data analysis as dictated by their individual project needs. The Core is able to provide experience in performing research using clinical specimens, the necessary technical expertise in a wide range of molecular and bioassays, access to equipment and resources enabling cutting-edge approaches to address research questions, quality control assessment of the data collected and data processing suitable for higher end statistical modeling of phenotype/clinical associations. Therefore, the goals of the Phenotyping Core can be summarized as follows: Goal 1: Offer expert consulting for experimental project design, cost analysis, implementation planning and project management for ORDRCC investigators. Goal 2: Provide access to advanced technology, centralized equipment and experienced personnel for high throughput/high content experimental phenotype characterization and biomarker assays in genetic, genomic, proteomic, immune phenotype and immune functional domains. Goal 3: Supply guidance on data quality control, processing of raw data, and preparation of data sets for more extensive statistical modeling. Goal 4: Assess and develop new cutting edge technologies for phenotype characterization.