Michigan Center on Lifestage Environmental Exposures and Disease

摘要/摘要(管理核心) 密歇根生命环境暴露和疾病中心(M-LEEAD)任务有两个 首要目标：加快研究，定义和解释环境暴露的影响 促进将这些研究成果转化为改善医疗和公共卫生的方法 减轻人类疾病的干预措施。我们通过综合研究来执行我们的使命， 由行政核心监督的培训和社区参与。行政核心由以下人员领导 中心主任在副主任的协助下。这个核心是试点的行政单位 项目方案(由副主任领导)、职业发展方案(由副主任领导)和 研究参与计划(由副主任领导)。三个研究小组(炎症和 氧化应激团队；内分泌和代谢紊乱；遗传学和表观遗传学调控)是 研究参与计划的要素，研究团队领导人包括在 管理核心。研究团队是成员探索新合作和 协调对融资机会的反应。包括试点项目方案、职业生涯的领导力 行政核心的开发计划和研究参与计划针对该中心 目标是这些项目以综合的方式运作。行政核心学院将由 行政助理和网页设计师/管理员。核心作为协作团队工作，以提供 一个有效和高效的行政基础设施，以实现M-Leead的使命。核心是 负责组织M-Lead会议、务虚会、顾问访问、座谈会、 研讨会和焦点小组，并保存报告、会议纪要和评估结果的记录 事件。此外，该核心还提供对预算的受托监督。核心获取并考虑输入 关于环境健康科学和新发现的新兴理论、范式、技术和发现 多层次的生物医学，从研究小组报告到董事会议再到内部咨询委员会 会议，包括外部咨询委员会。行政核心对职业生涯负有责任 开发计划和试点项目计划，确保这些计划鼓励创新 研究面向所有成员，尤其是针对早期调查人员。核心确保将输入包括在 社区参与的机会，并促进M-Lead科学家之间的多方向对话， 社区成员和监管利益相关者。核心协调对紧急环境的反应 危害和关切，包括与NIEHS其他环境健康科学核心中心的互动， NIEHS和其他相关组织。最后，核心负责评估 以计划、核心和活动为中心，采取必要的纠正措施。

SUMMARY/ABSTRACT (Administrative Core) The Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) mission has two overarching goals: to accelerate research that defines and explains impacts of environmental exposures during vulnerable stages of life, and to promote translation of these findings to improve medical and public health interventions for the mitigation of human disease. We implement our mission through integrated research, training and community engagement overseen by the Administrative Core. The Administrative Core is led by the center director with assistance from the deputy director. This core is the administrative unit for the Pilot Project Program (led by the deputy director), Career Development Program (led by an Associate Director), and Research Engagement Program (led by an Associate Director). Three Research Teams (Inflammation & Oxidative Stress Team; Endocrine & Metabolic Disruption; and Genetics & Epigenetics Regulation) are elements of the Research Engagement Program with research team leaders included as members of the Administrative Core. The research teams are key mechanisms for members to explore new collaborations and for coordinating responses to funding opportunities. Inclusion of leadership of the Pilot Project Program, Career Development Program, and Research Engagement Program in the Administrative Core addresses the center objective that these programs operate in an integrative manner. Administrative Core Faculty will be assisted by an administrative assistant and web designer/administrator. The core works as collaborative team to provide an effective and efficient administrative infrastructure to achieve the mission of M-LEEaD. The core is responsible for organizing M-LEEaD activities such as meetings, retreats, consultant visits, symposia, seminars, and focus groups, and maintaining records of reports, minutes, and evaluation results from such events. In addition, the core provides fiduciary oversight of the budgets. The core obtains and considers input on emerging theories, paradigms, technologies, and discoveries in environmental health sciences and biomedicine at multiple levels, from research team reports to director meetings to Internal Advisory Committee meetings and including the External Advisory Board. The Administrative Core has responsibility for the Career Development Program and the Pilot Project Program, ensuring that these programs encourage innovative research for all members, but especially for early-stage investigators. The core ensures inclusion of input on opportunities for community engagement and fosters multi-directional dialogue among M-LEEaD scientists, community members, and regulatory stakeholders. The core coordinates responses to urgent environmental hazards and concerns, including interactions with other NIEHS Environmental Health Sciences Core Centers, the NIEHS, and other relevant organizations. Finally, the core is responsible for evaluation of the efficacy of the center programs, cores, and activities, taking corrective action as warranted.