Boston Roybal Center for Active Lifestyle Interventions

波士顿罗伊巴尔积极生活方式干预中心（RALI Boston）的总体目标是开发和 测试行为改变策略，以促进健康老龄化，特别是在久坐的成年人和其他人中， 健康状况不佳的高风险。众所周知，体育活动对身体， 心理和认知方面的健康。然而，中年和老年人的人数， 定期活动仍然很低。此RALI Boston续约申请侧重于RFA的主题#2： “促进身体活动，以创建、修改和试点测试基于原则的干预措施， 行为和增加身体活动。”该项目的具体目标是：1）进行创新的临床 试验基于坚实的研究证据，并使用NIH阶段模型，可以转化为增加 在中年和老年人的身体活动作为一种手段，以健康老龄化，2）推进研究 通过识别和测试导致行为改变的机制， 增加身体活动和改善健康和福祉，3）提供必要的科学知识 和资源，以促进创新的跨学科研究和翻译，通过领导和协调 五所大学和社区组织的项目。这些目标将通过以下两个方面来实现： 核心，管理和行政核心和试点核心。我们将开发新的行为改变 战略，评估他们如何在临床试验中与不同的弱势群体，并评估是否 他们导致身体活动的持续变化，使用有效的措施， 在我们的RALI调查员。最终，我们将利用获得的信息来完善技术， 更新我们的概念框架，并将开发和测试全面的翻译干预措施，旨在 改善中老年活动、健康和生活质量。该中心的特点是 一系列创新功能：1）认识到人类行为的多种影响， 复杂的方式，并适用于一个独特的多组件模型的行为改变; 2）使用个性化的 方法，并根据个人特点和背景调整拟议的干预措施， 3）扩大我们的重点，包括基本的神经机制和其他介质的人 通过采用新的成像方法和非侵入性电刺激改变行为; 4）关注 服务不足的弱势中年和老年人群体面临健康状况不佳的风险， 与社区组织合作，为不同的中老年人提供服务，他们将从 中心活动; 5）使用共同的核心行为措施，使我们能够比较结果， 不同的试点研究干预措施; 6）成功地吸引了一个致力于跨学科的高级团队， 调查人员带来了来自五所大学的多种专业观点和广泛的资源： 布兰迪斯大学，波士顿大学，波士顿学院，东北大学，哈佛医学院/希伯来高级生活。

The overall goal of the Boston Roybal Center for Active Lifestyle Interventions (RALI Boston) is to develop and test behavior change strategies to promote healthy aging, especially among sedentary adults and others at high risk for poor health outcomes. It is widely known that physical activity is broadly beneficial for physical, psychological, and cognitive aspects of health. However, the number of middle-aged and older adults who are regularly active remains quite low. This RALI Boston renewal application focuses on theme #2 from the RFA: “Physical activity promotion to create, modify and pilot test principle-based interventions to reduce sedentary behavior and increase physical activity.” The specific aims of the project are to: 1) conduct innovative clinical trials based on solid research evidence and using the NIH Stage Model that can be translated to increase physical activity in middle-aged and older adults as a means to healthy aging, 2) advance research on behavior change processes in intervention research by identifying and testing the mechanisms that lead to increases in physical activity and improved health and well-being, 3) provide the necessary scientific expertise and resources to facilitate innovative interdisciplinary research and translation by leading and coordinating projects across five universities and community organizations. These aims will be accomplished through two cores, the Management and Administration Core and the Pilot Core. We will develop novel behavior change strategies, evaluate how they work in clinical trials with different vulnerable populations, and assess whether they lead to sustained changes in physical activity, using well-validated measures that are available to investigators in our RALI Toolbox. Ultimately, we will use the information gained to refine the techniques and update our conceptual framework, and will develop and test full scale translational interventions designed to improve activity, health and quality of life among middle-aged and older adults. The Center is distinguished by a number of innovative features: It 1) recognizes the multiple influences on human behavior that interact in complex ways and applies a unique multi-component model of behavior change; 2) uses a personalized approach and adapts the proposed interventions according to the individual characteristics and contextual circumstances of the person; 3) expands our focus to include basic neural mechanisms and other mediators of behavior change by employing novel imaging methods and noninvasive electrical stimulation; 4) focuses on underserved, vulnerable populations of middle-aged and elderly adults at risk for poor health outcomes and partners with community organizations serving diverse middle-aged and older adults who will benefit from the Center activities; 5) uses a common core of behavioral measures that will enable us to compare results of different pilot study interventions; 6) has successfully engaged a committed, interdisciplinary team of senior investigators who bring multiple professional perspectives and extensive resources from five universities: Brandeis U, Boston U., Boston College, Northeastern U., Harvard Medical School/Hebrew Senior Life.