Pilot/Exploratory Studies Core (PESC)

项目总结/摘要-初步和探索性研究核心（PESC） 杜克OAIC的试点/探索性研究核心（PESC）的目标是进行高质量的试点 项目，通知选择，设计，并在我们的后续更大的，假设驱动的研究进行 主题：了解和优化储备和复原力。具体目标是：1）提高质量 与晚年储备和恢复力有关的科学，2）吸引和培养一个多样化的优秀早期干部， 研究人员在老龄化研究或建立研究人员追求有前途的新方向有关我们的 3）与关键利益相关者建立和保持关系，以最大限度地发挥影响和转化 通过本组织和今后的组织间委员会开展的工作。通过利用机构资金，我们将支持 每年至少三个试点项目。我们使用小额探索性试点资金作为快速反应机制， 利用最前沿的领域。PESC征求并选择来自全国各地的高质量试点研究 杜克大学医学中心采用严格的多阶段流程，包括内部和外部 审查. PESC仔细监测研究进展，并协助制定更大的赠款提案 从试点研究的结果。为了实现我们的目标，杜克PESC包括几个高度创新的功能： 1)试点赠款研讨会，由OAIC主任Kenneth Schmader开发， 2）将患者/社区代表纳入选择试点的审查小组，3） 数据集成工作组，这是科学发展，监督和促进的中心枢纽 翻译，以及4）支持未资助的试点研究申请人的科学和职业的机制。四 在头两年提出试点项目。PES 1研究了预处理的可行性和有效性， 手术运动干预（“prehistory”），以提高老年人的适应力， 手术PES 2研究了瞬时受体电位香草酸4（TRPV 4）介导的机械- 转导在恢复旧软骨细胞的储备能力，潜在地提高他们的能力， 承受生理负荷，避免骨关节炎。PES 3将证明衰老对自噬的影响 在肌肉干细胞中，寻找增强肌肉储备和减少 肌肉减少症PES 4结合了临床和生物学数据，以开发在以下方面有用的临床预测规则： 预测接受化疗的老年多发性骨髓瘤患者的恢复力。PESC影响公众 通过研究发展知识，以保持或恢复美国老年人的独立性， 在面对慢性和急性压力源时，促进储备和复原力。

PROJECT SUMMARY/ABSTRACT – Pilot and Exploratory Studies Core (PESC) The objective of the Pilot/Exploratory Studies Core (PESC) of the Duke OAIC is to conduct high quality Pilot Projects that inform the selection, design, and conduct of subsequent larger, hypothesis-driven research in our theme: to understand and optimize reserve and resilience. The Specific Aims are to: 1) advance top quality science related to late-life reserve and resilience, 2) attract and nurture a diverse cadre of outstanding early investigators in aging research or established investigators pursuing promising new directions related to our theme, and 3) build and sustain relationships with critical stakeholders to maximize the impact and translation of the work conducted through this and future OAICs. By leveraging institutional funding, we will support at least three Pilot Projects per year. We use small exploratory pilot monies as a rapid response mechanism to take advantage of cutting edge areas. The PESC solicits and selects high quality pilot studies from across Duke University Medical Center using a rigorous, multi-stage process that incorporates internal and external review. The PESC carefully monitors study progress and assists in the development of larger grant proposals from pilot study findings. To accomplish our Aims, the Duke PESC includes several highly innovative features: 1) the Pilot Grants Workshop, developed by OAIC Director Kenneth Schmader and frequently requested in national venues, 2) the inclusion of patient/community representatives on the Review Panel selecting pilots, 3) the Data Integration Working Group, which is a central hub for scientific development, oversight, and promoting translation, and 4) mechanisms that support the science and careers of unfunded pilot study applicants. Four Pilot Projects are proposed in the first two years. PES1 investigates the feasibility and efficacy of a pre- operative exercise intervention (“prehabilitation”) to enhance resilience for older adults undergoing elective surgery. PES2 investigates the role of transient receptor potential vanilloid 4 (TRPV4)-mediated mechano- transduction in restoring the reserve capacity of old chondrocytes, potentially improving their ability to withstand physiological load and avoid osteoarthritis. PES3 will demonstrate the effect of aging on autophagy in muscle stem cells and seek specific mechanistic targets for enhancing muscle reserve and reducing sarcopenia. PES4 incorporates clinical and biological data to develop clinical prediction rules useful in predicting resilience in older multiple myeloma patients undergoing chemotherapy. The PESC impacts public health by performing studies that develop knowledge to maintain or recover independence in older Americans, by promoting reserve and resilience in the face of chronic and acute stressors.