Baylor College of Medicine Cancer Center

 描述（由申请人提供）：癌症生物学项目CBP的总体目标是增加我们对癌症发展和进展的基本遗传、分子和生物学机制的理解，并促进这些发现的转化，以改善诊断、治疗和预防措施。CBP由51名研究成员，14名临床成员和2名兼职成员组成。成员包括14个部门和2个中心，其中2名成员来自其他机构。成员有450万美元的NCI资助的研究支持，总额为3060万美元的研究支持。CBP计划的生产力很高，共有685篇出版物，其中15%是计划内出版物，19%是计划间出版物。该计划已细分为4个相互依存的主题：计算生物学，功能基因组学，细胞信号传导和翻译。计算主题使用基因组学、转录组学、蛋白质组学和代谢组学数据的生物信息学分析，以确定临床相关途径，用于开发治疗试剂或潜在生物标志物，以进行临床前验证研究。功能基因组学主题使用基因工程小鼠模型和患者来源的异种移植物分析来确定计算生物学主题所确定的人类癌症中遗传改变的意义。细胞信号转导主题的功能是对计算和功能基因组学主题确定的信号转导通路进行体外机制分析，以确定这些通路如何调节癌症的发生、进展和转移。该小组的作用是确定哪些途径是生物标志物或治疗开发的目标。最后，翻译主题由临床研究人员和参与新疗法开发的研究人员组成。该主题的目的是促进基础科学发现的翻译 CBP的病人。该小组帮助CBP研究人员确定如何将这些发现转化为治疗癌症的疗法和生物标志物的开发。

 DESCRIPTION (provided by applicant): The overarching goal of the Cancer Biology Program, CBP, is to increase our understanding of the basic genetic, molecular, and biological mechanisms of cancer development and progression and to facilitate the translation of these findings for improved diagnostic, therapeutic, and preventative measures. The CBP consists of 51 Research Members, 14 Clinical Members, and 2 Adjunct Members. The membership spans 14 departments, and 2 centers, with two members from other institutions. The membership has $4.5 million in NCI funded research support out of a total of $30.6 million in total research support. The CBP program is highly productive with a total of 685 publications with 15% of the publications being intra-programmatic and 19% inter-programmatic. The program has been subdivided into 4 interdependent themes: Computational Biology, Functional Genomics, Cell Signaling, and Translation. The Computational Theme uses bioinformatic analyses of genomic, transcriptomic, proteomic, and metabolomic data to identify clinically relevant pathways for the development of therapeutic reagents or potential biomarkers to be moved to preclinical validation studies. The Functional Genomics Theme uses genetically engineered mouse models and patient-derived xenograft analysis to determine the significance of genetic alterations in human cancer as identified by the Computational Biology Theme. The Cell Signaling Theme functions to conduct in vitro mechanistic analysis of signaling pathways identified by the Computational and Functional Genomics Theme to determine how these pathways regulate cancer initiation, progression, and metastasis. The role of this group is to identify which pathways are targets for biomarkers or therapeutic development. Finally, the Translational Theme consists of clinical researchers and researchers involved in development of novel therapeutics. The goal of this Theme is to facilitate the translation of the basic science findings of the CBP to the patient. This group aids CBP researchers in determining how these findings can be translated to the development of therapies and biomarkers for the treatment of cancer.