Optimization of Drug Dosing in Pregnant Women through Research and Education

 描述（由申请人提供）：通过研究和教育优化孕妇的药物剂量。 本提案的主要目标是：1.通过更好地了解药物的药代动力学和药效学来优化孕妇的药物治疗，通过在匹兹堡大学多学科产科和胎儿药理学研究中心（OPRC）与其他OPRC合作进行基础，转化和临床研究;和2。制定新的战略，以吸引，教育和培训下一代产科-胎儿药理学的临床和基础科学研究人员。这些目标解决了产科药理学的迫切需要，即缺乏足够的科学信息来指导孕妇及其医疗保健提供者正确的剂量和药物的安全性。关于药物对婴儿影响的信息不完整，主要限于畸形风险;关于药物对婴儿长期影响的信息很少。在本提案中，我们描述了匹兹堡OPRC通过与其他OPRC站点以及我们站点的基础和转化研究合作进行临床研究来扩展对药物的理解的能力。我们实现这些药理学目标的方法是基于我们在过去10年中作为OPRU一部分使用的方法。我们还提出了创新的方法，以吸引，教育和培训未来的研究人员在产科药理学领域利用我们已经在我们的T32计划在产科药理学3年完善的方法。我们将扩大这些方法，针对产妇-胎儿医学培训计划的学员。

 DESCRIPTION (provided by applicant): Optimization of Drug Dosing in Pregnant Women through Research and Education. The main objectives of this proposal are: 1. To optimize pharmacotherapy in pregnant women through a better understanding of the pharmacokinetics and pharmacodynamics of medications, by performing basic, translational and clinical research at the multidisciplinary Obstetric and Fetal Pharmacology Research Center (OPRC) at the University of Pittsburgh in collaboration with other OPRCs; and 2. To develop novel strategies to attract, educate and train the next generation of clinical and basic science researchers in Obstetric-Fetal Pharmacology. These aims address a pressing need in Obstetric Pharmacology that being insufficient scientific information to guide pregnant women and their health care provider on the proper dosing and safety of medications. Information on effects of medications on infants is incomplete and limited mostly to risks of malformations; little information exists about the long term effects of medication on the infant. In this proposal we describe the capabilities at the Pittsburgh OPRC to expand the understanding of medications by performing clinical research collaboratively with other OPRC sites and basic and translational research at our site. Our methods for achieving these pharmacotherapeutic goals are based on those methodologies we have used as part of the OPRU for the last 10 years. We also propose innovative approaches to attract, educate and train future researchers in the field of Obstetric Pharmacology utilizing methods we have refined during 3 years of our T32 program in Obstetric Pharmacology. We will expand those methodologies by targeting trainees in Maternal- Fetal Medicine training programs.