Multiple paths of TFH differentiation and their impact on B cell protection against infection

T和B细胞之间的合作对于免疫保护至关重要，也是当前疫苗策略的基础。我们已经揭示了T细胞反应中存在的一种不为人知的灵活性，这种灵活性改变了它们给B细胞的指令。这很可能是定制的免疫反应，以确保对无数传染病的保护。该项目使用尖端技术来理解这种灵活性，并对传染病的疫苗设计和治疗具有重要影响。

Collaboration between T and B cells is crucial for immune protection and underpins current vaccine strategies. We have revealed an unappreciated flexibility that exists in T cell responses which varies the instructions they give B cells. It is likely this tailors immune responses to ensure protection to countless infectious diseases. This project uses cutting-edge technologies to understand this flexibility and has important implications for vaccine design and treatment of infectious disease.