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Computational modeling of human metabolism, body weight and composition

Computational modeling of human metabolism, body weight and composition
人体新陈代谢、体重和成分的计算模型
批准号：
9553216
负责人：
KEVIN HALL
金额：
$31.17万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9553216
关键词：
AffectAnorexia NervosaBehaviorBiological SciencesBody CompositionBody WeightBody Weight ChangesCachexiaClinicalClinical ManagementClinical SciencesComplexComputer SimulationDesire for foodDiseaseEnergy MetabolismEngineeringFeedbackGoalsHumanInterventionKilogramKnowledgeMalnutritionMetabolicMetabolic DiseasesMetabolismObesityRegulationResearchSystemWasting SyndromeWeightdesignexperimental studyincreased appetitemathematical modelphysical sciencetoolweight loss intervention

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中文摘要
翻译
我们继续发展人体新陈代谢和体重动态的数学模型。我们的数学模型最近被用于提供人类食欲反馈控制的第一个量化。我们发现，当人们减肥时，每减轻一公斤体重，食欲就会比基线增加约100千卡/天。这种反馈控制机制有助于解释为什么减肥干预通常会在第一年导致平稳期，以及为什么减肥和长期保持体重如此困难。
英文摘要
We continue to develop mathematical models of human metabolism and body weight dynamics. Our mathematical model was recently used to provide the first quantification of feedback control of appetite in humans. We found that as people lose weight, appetite increases by about 100 kcal/d above baseline for every kilogram of lost weight. This feedback control mechanism helps explain why weight loss interventions typically result in a plateau within the first year and why it is so difficult to lose weight and keep it off over the long term.
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Interactions of diet, exercise, metabolism, and weight change in humans
Regulation of rodent energy metabolism, body weight and composition
Computational modeling of human metabolism, body weight and composition
Regulation of rodent energy metabolism, body weight and composition
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