Training in Translational Science and Cardiovascular Medicine

描述（由申请人提供）：本延续提案旨在为应用于心血管疾病的转化研究的培训计划提供资金。该计划通过俄勒冈州健康与科学大学心血管医学部和心脏研究中心招募博士和医学博士学员。每年有六名博士后研究员获得两年研究培训的资助。该计划提供了令人兴奋的机会，在三个既定的小组之一，专门从事1）肥胖/糖尿病，2）发展规划，3）监管过程的板凳到床边的培训。28名教师是高度认可和资助的科学家，他们在培养博士后研究员方面有着良好的记录。专业培训包括分子成像，小鼠遗传模型，肥胖和心血管疾病的灵长类动物模型，临床MRI研究，机械力-基因表达联系，生物工程血管元素，心血管失调的数学模型。实验室研究是由课程工作，研讨会，期刊俱乐部，并在一个特定的科学组会议的补充。所有学员都参加了研究培训和团队科学方法的负责任行为。该计划在OHSU是独一无二的，因为指导是以团队的方式进行的，并且因为该培训计划是专门设计用于将基础研究转化为临床益处的。 每个学员的指导委员会由一名基础科学家和一名临床科学家以及一名其他科学家组成。培训的结果将是科学家具有广阔的前景，并专注于把科学带到床边。该申请包括一个强有力的招聘计划，为服务不足的少数民族学员和评估过程。 一个强大的计划咨询委员会监控每个学员的进展，因为他们满足特定的里程碑，为研究生涯做准备。从该计划毕业的科学家将准备调查主要的公共卫生问题，包括中风，糖尿病，冠心病，心力衰竭和肥胖症日益增加的全球负担。 (End摘要）

DESCRIPTION (provided by applicant): This continuation proposal seeks funds for a training program in translational research applied to cardiovascular disease. The program recruits PhD and MD trainees through the Division of Cardiovascular Medicine at Oregon Health & Science University and the Heart Research Center. Six post-doctoral fellows per year are offered funding for two years of research training. The program offers exciting opportunities for bench to bedside training in one of three established groups that specialize in 1) obesity/diabetes, 2) developmental programming, and 3) regulatory processes. The 28 faculty are highly recognized and funded scientists who have a track record of training postdoctoral fellows. Specialty training includes molecular imaging, mouse genetic models, primate models of obesity and cardiovascular disease, clinical MRI research, mechanical forces-gene expression links, bioengineering vascular elements, mathematical models of cardiovascular dysregulation. Laboratory research is supplemented by course work, seminars, journal club, and meetings within a specific science group. All trainees participate in Responsible Conduct of Research training and team science methods. This program is unique at OHSU in that mentoring is carried out in a team approach and because this training program is specifically designed to translate basic research into clinical benefit. A basic scientist and a clinical scientist plus on additional scientist serve on each trainee's mentoring committee. The training outcome will be scientists with a broad outlook and a focus on bringing science to the bedside. The application includes a strong recruitment program for underserved minority trainees and an evaluation process. A strong Program Advisory Committee monitors the progress of every trainee as they meet specific mileposts in preparation for a research career. The scientists that graduate from this program will be prepared to investigate major public health issues including the increasing global burden of stroke, diabetes, coronary heart disease, heart failure and obesity. (End of Abstract)