Training Program in Oncogenic Signals and Chromosome Biology

项目摘要 这是加州大学戴维斯分校博士后T32项目的第二次更新申请， 染色体生物学寻求资金11 - 15年。该培训计划利用综合 分子肿瘤学计划在加州大学戴维斯分校NCI指定的综合癌症中心的实力 以及参与研究的教职员工在致癌信号方面的特殊专业知识和培训记录 和染色体生物学。该计划涉及18名培训师，包括两名国家学院成员， 一名HHMI调查员，加上五名初级导师，努力培养下一代培训师。每 教练保持一个积极的，校外资助的研究计划。这个项目的翻译方面 在癌症中心强大的临床研究组成部分的推动下， 戴维斯临床和转化科学中心。在前两个资助期内，培训计划 任命了27名优秀的博士后研究员，其中8名来自代表性不足的国家 少数民族和8名研究员，他们从非常不同的科学领域进入癌症生物学。值得注意的是，9 研究员获得了竞争性的个人研究金，继续接受癌症生物学培训。培训 该计划开发了一系列创新和有效的课程活动，确保个人的灵活性 并提供致癌信号和染色体生物学方面的正式培训， 开展研究，以及个性化的辅导和职业发展。列入培训 课程是一个丰富多样的研讨会，会议，讨论小组，讲习班和务虚会 提供机会，介绍研究进展，并扩大培训经验， 教练的实验室该培训计划为大学增加了重要价值，因为它为一群 138人，其中包括39名在上一个资助期内符合培训补助金条件的博士后研究员，他们积极参与 一些培训补助金活动。一个有效的行政结构已经到位，并在这方面得到进一步完善。 退款董事在一个活跃的执行委员会的指导下管理该计划， 它积极维护特定的投资组合以增强计划活动。进一步发展培训 我们聘请了一个四人顾问委员会的帮助。两名外部顾问具有以下经验： 类似的癌症导向培训项目的负责人。两名内部成员经验丰富 导师，包括医学院副院长，谁是指导和共同PI的权威， UC Davis BEST/Future由NIH资助。培训计划旨在为我们的学员做好准备， 奖励生物医学劳动力的职业生涯，并使他们能够做出广泛的明智决策 可能的职业轨迹。

Project Summary This is the second renewal application for the UC Davis postdoctoral T32 program in Oncogenic Signals and Chromosome Biology seeking funding for years 11-15. This training program takes advantage of the integrated strength of the Molecular Oncology Program at the UC Davis NCI-designated Comprehensive Cancer Center and the exceptional expertise and training records of the participating faculty members in oncogenic signals and chromosome biology. The program involves 18 trainers, including two National Academy members and one HHMI Investigator, plus five junior mentors in an effort to develop the next generation of trainers. Every trainer maintains an active, extramurally funded research program. The translational aspects of this program are facilitated by a strong clinical research component at the Cancer Center, with further support from the UC Davis Clinical and Translational Science Center. Over the first two funding periods, the training program appointed an outstanding cohort of 27 highly talented postdoctoral fellows including 8 from underrepresented minorities and 8 fellows who crossed into cancer biology from very different areas of science. Remarkably, 9 fellows obtained competitive, individual fellowships to continue their training in cancer biology. The training program has developed an innovative and effective array of curricular activities that insures individual flexibility and provides formal training in oncogenic signals and chromosome biology, education in the responsible conduct of research, as well as individualized mentoring and career development. Included in the training curriculum are a rich and diverse array of seminars, conferences, discussion groups, workshops, and retreats that provide opportunities to present research progress and broaden the training experience beyond the trainer's laboratory. The training program added significant value to the university, as it serviced a cohort of 138 including 39 training grant eligible postdoctoral fellows in the last funding period, who actively participate in some training grant activities. An effective administrative structure is in place that is further refined in this renewal. A director administers the program with guidance by an active executive committee, each member of which actively maintains a specific portfolio to enhance the program activities. To further develop the training program, we employ the help of a four-member Advisory Board. The two external advisors have experience as directors of comparable cancer-oriented training programs. The two internal members are highly experienced mentors and include the Vice Dean of the School of Medicine, who is an authority in mentoring and co-PI of the UC Davis BEST/Future grant supported by NIH. The training program aims to prepare our trainees for rewarding careers in the biomedical workforce and empower them to make informed decisions of the breadth of possible career tracks.