Muscle thermogenesis in models of predisposition to obesity

肥胖是一个主要的健康危机，但有效的治疗方法仍然难以捉摸。体重是由食物摄入和能量消耗的平衡决定的。了解这个等式的两边对于对抗肥胖至关重要。该项目将表明，肌肉使用能量的速率是能量平衡的重要决定因素，并有助于肥胖的倾向。这项工作将肌肉定义为开发抗肥胖疗法的目标。

Obesity is a major health crisis, but effective treatments remain elusive. Body weight is determined by a balance of food intake and energy expenditure. Understanding both sides of this equation is essential to combating obesity. This project will show that the rate at which muscle uses energy is an important determinant of energy balance and contributes to the propensity to become obese. The work will define muscle as a target for developing anti-obesity therapies.