Animal Model Core

动物模型核心-摘要 每个有前途的初级研究员(PJI)至少有有限的动物研究经验 并需要在体内验证体外研究结果。因此，始终如一的关怀，实验性的 程序和畜牧业对项目的成功很重要。因此， 目标为动物模型核心(AMC)将确保项目实验 一致性，遵守联邦动物福利法规，并提供帮助 在呼吸系统疾病动物模型的前沿表型研究中。这将是 包括关于机构规章和要求的说明 动物保护和利用委员会(IACUC)。AMC将维护IACUC协议，用于 它向非中心个人提供的服务。此外，辛斯代尔博士将协助 PJI具有各自的IACUC协议。一些调查人员将不得不保持 俄克拉何马州立大学和俄克拉何马健康大学批准的动物使用协议 科学中心(OUHSC)。所有项目负责人将在俄亥俄州立大学实验室充分活跃 动物资源(LAR)培训计划，包括IACUC政策培训。在……里面 此外，所有AMC工作人员和参与任何动物手术的人员都将参加 俄亥俄州立大学劳尔职业健康计划。OSU LAR设施完全是AAALAC 经认证的OSU LAR护理和使用计划满足AAALAC关于 IACUC的组成和活动。IACUC有13个成员，其中 7名科学家代表，2名实验动物兽医代表，2名 兽医代表和2名公众代表。适用于 实验动物保护和使用计划IACUC负有最终责任。这些 活动将向PJI传达IACUC对其研究活动的重要性。 最后，AMC将培训PJI如何管理和维护动物模型。作为一名 由于AMC在第一阶段的运营，该机构升级了最先进的BSL2 动物舍设施，获得最先进的呼吸模型表型，以及 俄亥俄州立大学静水分校OCRID研究人员之间的互动和培训的增加， 俄亥俄州立大学塔尔萨分校、俄克拉何马城分校、俄克拉何马州诺曼分校和俄克拉何马城分校。

Animal Models Core-Abstract Each promising junior investigator (PJI) has at least limited animal research experience and needs to verify in vitro findings in vivo. As a result, consistent care, experimental procedures, and husbandry are important to the success of the projects. Therefore, the objective for the Animal Models Core (AMC) will be to ensure project experimental consistency, compliance with federal animal welfare regulations, and assistance in cutting-edge phenotyping of animal models of respiratory disease. This will include instruction in regards to the regulations and requirements of the Institutional Animal Care and Use Committee (IACUC). The AMC will maintain an IACUC protocol for the services it provides to non-Center individuals. In addition, Dr. Hinsdale will assist the PJIs with their individual IACUC protocols. Some investigators will have to maintain approved animal use protocols at both OSU and the University of Oklahoma Health Sciences Center (OUHSC). All project leaders will be fully active in the OSU Laboratory Animal Resources (LAR) training program that includes IACUC policy training. In addition, all AMC staff and those involved in any animal procedures will participate in the OSU LAR occupational health program. The OSU LAR facility is fully AAALAC accredited and the OSU LAR care and use program satisfies the AAALAC guidelines for the composition and activity of the IACUC. The IACUC has 13 members where there are 7 scientist representatives, 2 laboratory animal veterinarian representatives, 2 veterinarian representatives, and 2 public representatives. For operation of the laboratory animal care and use program the IACUC has ultimate responsibility. These activities will convey to the PJIs, the importance of the IACUC to their research activities. Lastly, the AMC will train the PJIs on how to manage and maintain animal models. As a result of AMC operations in Phase I, the institution has upgraded state-of-the art BSL2 animal housing facilities, access to cutting edge phenotyping of respiratory models, and increased interactions between and training of OCRID researchers at OSU Stillwater, OSU Tulsa, OU Oklahoma City, OU Norman and OMRF Oklahoma City.